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Cotellic

Cotellic

Manufacturer:

Roche

Distributor:

Firma Chun Cheong
/
DKSH
Concise Prescribing Info
Contents
Cobimetinib
Indications/Uses
In combination w/ vemurafenib for the treatment of adult patients w/ unresectable or metastatic melanoma w/ a BRAF V600 mutation.
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Dosage/Direction for Use
PO 60 mg once daily for 21 consecutive days followed by a 7-day break.
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Overdosage
View Cotellic overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity.
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Special Precautions
Patients must have BRAF V600 mutation +ve tumour status confirmed by a validated test before treatment. Assess symptoms of new or worsening visual disturbances. Evaluate LVEF before initiation, then after the 1st mth of treatment & at least every 3 mth or as clinically indicated until treatment discontinuation. Monitor liver value abnormalities. Diarrhoea, lactose intolerance; QT prolongation. Concomitant use w/ strong/moderate CYP3A inhibitors. Pregnancy & lactation.
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Adverse Reactions
Anaemia; serous retinopathy; HTN, haemorrhage; diarrhoea, nausea, vomiting; photosensitivity, rash, maculo-papular rash, dermatitis acneiform, hyperkeratosis; pyrexia; increased blood CPK, ALT, AST, γ-glutamyltransferase (GGT) & blood ALP. Basal cell carcinoma, cutaneous squamous cell carcinoma, keratoacanthoma; dehydration, hypophosphataemia, hyponatremia, hyperglycaemia; blurred vision, visual impairment; pneumonitis; chills; decreased ejection fraction & blood bilirubin.
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Drug Interactions
Increased AUC w/ strong/moderate CYP3A inhibitors & P-glycoprotein (P-gp) inhibitors. Reduced exposure w/ strong CYP3A inducers.
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Cotellic detailed prescribing information
Storage
View Cotellic storage conditions for details to ensure optimal shelf-life.
Description
View Cotellic description for details of the chemical structure and excipients (inactive components).
Action
View Cotellic mechanism of action for pharmacodynamics and pharmacokinetics details.
ATC Classification
L01XE38 - cobimetinib ; Belongs to the class of protein kinase inhibitors, other antineoplastic agents. Used in the treatment of cancer.
Presentation/Packing
Form
Cotellic FC tab 20 mg
Packing/Price
63's
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