Loading dose: 200 mg of isavuconazole every 8 hr for the 1st 48 hr. Maintenance dose: 200 mg of isavuconazole once daily, starting 12-24 hr after the last loading dose. No dose adjustment is needed for elderly or patient w/ renal/hepatic impairment. Infusion
To be reconstituted & then further diluted to a conc corresponding to approx 0.8 mg/mL isavuconazole prior to administration by IV infusion over a min of 1 hr. Must only be given as an IV infusion. On the basis of high oral bioavailability (98%), switching between IV & oral administration is appropriate when clinically indicated.