Cubicin

Cubicin

daptomycin

Manufacturer:

MSD

Distributor:

Zuellig
/
Agencia Lei Va Hong
Concise Prescribing Info
Contents
Daptomycin
Indications/Uses
Complicated skin & skin structure infections (cSSSI) caused by susceptible isolates of the following Gm +ve bacteria: Staph aureus (including methicillin-resistant isolates), Strep pyogenes, Strep agalactiae, & Strep dysgalactiae subsp. equisimilis. Staph aureus bloodstream infections (bacteremia) in adult patients, including right-sided infective endocarditis caused by methicillin-susceptible & -resistant isolates. Staph aureus bloodstream infections (bacteremia) in ped patients (1-17 yr).
Dosage/Direction for Use
cSSSI Adult 4 mg/kg by IV infusion in 0.9% NaCl inj over a 30-min period once every 24 hr for 7-14 days. Childn 12-17 yr 5 mg/kg once every 24 hr infused over 30 min for up to 14 days, 7-11 yr 7 mg/kg once every 24 hr infused over 30 min for up to 14 days, 2-6 yr 9 mg/kg once every 24 hr infused over 60 min for up to 14 days, 1 to <2 yr 10 mg/kg once every 24 hr infused over 60 min for up to 14 days. Staph aureus bloodstream infections Adult 6 mg/kg by IV infusion in 0.9% NaCl inj over a 30-min period once every 24 hr for 2-6 wk. Childn 12-17 yr 7 mg/kg once every 24 hr infused over 30 min for up to 42 days, 7-11 yr 9 mg/kg once every 24 hr infused over 30 min for up to 42 days, 1-6 yr 12 mg/kg once every 24 hr infused over 60 min for up to 42 days. Adult patients w/ renal impairment CrCl ≥30 mL/min cSSSI 4 mg/kg once every 24 hr. Staph aureus bloodstream infections 6 mg/kg once every 24 hr. CrCl <30 mL/min, including patients on hemodialysis or CAPD cSSSI 4 mg/kg once every 48 hr. Staph aureus bloodstream infections 6 mg/kg once every 48 hr.
Contraindications
Special Precautions
Reports of anaphylaxis/hypersensitivity reactions; myopathy & rhabdomyolysis; eosinophilic pneumonia; peripheral neuropathy; C. difficile-associated diarrhea (CDAD). Patients w/ persisting or relapsing Staph aureus bacteremia/endocarditis or poor clinical response. May promote overgrowth of nonsusceptible microorganisms. Significant conc-dependent false prothrombin time prolongation & INR elevation when certain recombinant thromboplastin reagents are used for the assay. Renal impairment. Pregnancy & lactation. Avoid use in ped patients <1 yr. Not indicated in ped patients w/ renal impairment. Elderly.
Adverse Reactions
Adult cSSSI trial: Diarrhea; headache, dizziness; rash; abnormal liver function tests, elevated CPK; UTI; hypotension; dyspnea. Ped cSSSI trial: Diarrhea, vomiting, abdominal pain; pruritus; pyrexia; blood CPK increased; headache. Adult S. aureus bacteremia/endocarditis trial: Sepsis, bacteremia; abdominal pain; chest pain, edema; pharyngolaryngeal pain; pruritus, sweating increased; insomnia; blood creatine phosphokinase increased; HTN. Ped S. aureus bacteremia trial: Vomiting; blood CPK increased.
Drug Interactions
Increased risk of myopathy w/ HMG-CoA reductase inhibitors.
MIMS Class
ATC Classification
J01XX09 - daptomycin ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.
Presentation/Packing
Form
Cubicin powd for inj 500 mg/10 mL
Packing/Price
1's
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