Agencia Lei Va Hong
Concise Prescribing Info
Treatment of premenstrual syndrome, including PMT & depression. Treatment of puerperal depression. Luteal phase support as part of an Assisted Reproductive Technology (ART) treatment for women.
Dosage/Direction for Use
Premenstrual syndrome & puerperal depression 200-400 mg once daily-bd, by vag or rectal insertion. Luteal phase support as part of an ART treatment 400 mg bd by vag insertion, starting at oocyte retrieval. Continue for 38 days for confirmed pregnancy.
Hypersensitivity, undiagnosed vag bleeding, known/suspected progesterone sensitive malignant tumours, porphyria, severe hepatic dysfunction/disease, known missed abortion/ectopic pregnancy, history or active arterial or venous thromboembolism or severe thrombophlebitis.
Special Precautions
Discontinue in the event of a missed miscarriage. Discontinue in case of suspected MI, cerebrovascular disorders, arterial or venous thromboembolism, thrombophlebitis or retinal thrombosis. Discontinue if symptoms of depression worsens. Patients w/ epilepsy, migraine, asthma, cardiac or renal dysfunction, or diabetes require careful observation. Patients w/ hormone-sensitive conditions (eg, 2nd half of menstrual cycle & pregnancy). Increased anxiety, moodiness & sensibility to seizures in abrupt progesterone discontinuation. Use rectally if barrier methods of contraception are used or if patients suffer from vag infection (especially moniliasis) or recurrent cystitis or have recently given birth. Use vaginally if patients suffer from colitis or fecal incontinence. Hepatic dysfunction. Pregnancy & lactation.
Adverse Reactions
Somnolence; abdominal pain, abdominal discomfort, constipation; breast pain; hot flush; fatigue.
Drug Interactions
Decreased bioavailability w/ drugs known to induce hepatic CYP3A4 system (eg, rifampicin, carbamazepine or phenytoin). Not recommended w/ other vag products.
MIMS Class
Oestrogens, Progesterones & Related Synthetic Drugs
ATC Classification
G03DA04 - progesterone ; Belongs to the class of pregnen (4) derivative progestogens.
Cyclogest supp 400 mg
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