Discontinue in the event of a missed miscarriage. Discontinue in case of suspected MI, cerebrovascular disorders, arterial or venous thromboembolism, thrombophlebitis or retinal thrombosis. Discontinue if symptoms of depression worsens. Patients w/ epilepsy, migraine, asthma, cardiac or renal dysfunction, or diabetes require careful observation. Patients w/ hormone-sensitive conditions (eg, 2nd half of menstrual cycle & pregnancy). Increased anxiety, moodiness & sensibility to seizures in abrupt progesterone discontinuation. Use rectally if barrier methods of contraception are used or if patients suffer from vag infection (especially moniliasis) or recurrent cystitis or have recently given birth. Use vaginally if patients suffer from colitis or fecal incontinence. Hepatic dysfunction. Pregnancy & lactation.