Dacogen

Dacogen

Manufacturer:

Janssen

Distributor:

DCH Auriga - Healthcare
/
Four Star
Concise Prescribing Info
Contents
Decitabine
Indications/Uses
Treatment of adults (≥65 yr) w/ newly diagnosed de novo or secondary AML, according to the WHO classification, who are not candidates for standard induction chemotherapy.
Dosage/Direction for Use
1 treatment cycle: 20 mg/m2 by IV infusion over 1 hr repeated daily for 5 consecutive days. Max total daily dose: 20 mg/m2. Max total dose per treatment cycle: 100 mg/m2. Repeat the cycle every 4 wk. Patient is recommended to be treated for a min of 4 cycles.
Contraindications
Special Precautions
Monitor for signs & symptoms of infection & treat promptly. Regularly perform complete blood & platelet count as clinically indicated & prior to each treatment cycle. History of severe CHF or clinically unstable cardiac disease. Hepatic & severe renal impairment. Patients w/ reduced kidney function or patients on a controlled K/Na diet. Women of childbearing potential & men must use effective contraceptive measures. Men should be advised not to father a child while on treatment, & for 3 mth following completion of treatment. Moderate influence on the ability to drive & use machines. Pregnancy. Childn <18 yr.
Adverse Reactions
Pneumonia, UTI, other infections (viral, bacterial, fungal); febrile neutropaenia, neutropaenia, thrombocytopaenia, anaemia, leukopaenia; headache; epistaxis; diarrhoea, vomiting, nausea; pyrexia. Septic shock, sepsis, sinusitis; hypersensitivity including anaphylactic reaction; stomatitis.
Drug Interactions
Potential for drug-drug interaction w/ other agents which are also activated by sequential phosphorylation (via intracellular phosphokinase activities) &/or metabolized by enzymes implicated in the inactivation of decitabine (eg, cytidine deaminase).
ATC Classification
L01BC08 - decitabine ; Belongs to the class of antimetabolites, pyrimidine analogues. Used in the treatment of cancer.
Presentation/Packing
Form
Dacogen powd for infusion 50 mg
Packing/Price
1's
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