Daunorubicin - Intravenous (Liposomal)

Patient Medicine Information
Why do I need this medicine?
Daunorubicin (liposomal) is a special formulation of Daunorubicin whereby this medicine is enclosed in a fatty coating. This helps to deliver more medicine to cancer tissue rather than healthy normal tissue.

Daunorubicin (liposomal) is used to treat severe Kaposi's sarcoma, a type of cancer that is often found in AIDS patients.
How do I use this medicine?
Daunorubicin (liposomal) is to be given intravenously (into the vein) via a drip. It is delivered directly into the bloodstream via the blood vessel. Doxorubicin (liposomal) is usually given over 30-60 minutes, depending of the dose used. You will need to rest in the hospital ward or clinic while you are on the drip.

Your doctor or nurse will administer the injection for you.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any dose.

If you miss an appointment with your doctor, arrange for a replacement appointment as soon as possible.

DO NOT double a dose under any circumstances.
When should I not use this medicine?
Do not use this medicine if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with this medicine, alert your doctor immediately. This medicine may cause harm to your unborn child. You must use proven birth control methods while using this medicine.

Do not use this medicine if you are breastfeeding.
What should I take note of while using this medicine?
Inform your doctor if you have liver disease or kidney disease.

If you are going for an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.

Keep your appointments with your doctor. You will need to have regular blood tests to check your blood counts as well as your liver and kidney function. You may also need to go for electrocardiogram (ECG) or echocardiogram to check how well your heart is functioning. Your doctor will advise you on how often you will need to have these tests.

Daunorubicin (liposomal) is not meant for use in children below 18 years old and in people above 65 years old. It is not known whether this medicine can be used safely or effectively in these people.
What side effects could I experience?
Daunorubicin (liposomal) may cause you to feel dizzy or weak. If affected, do not drive or take part in any activity in which you need to be alert.

Daunorubicin (liposomal) may also cause the level of your white blood cells to drop. Less commonly it may also cause the level of your red blood cells and platelets to drop.

White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever, or a cough or flu that does not go away.

Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.

Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).

Daunorubicin (liposomal) can cause serious side effects due to the drip. Alert your doctor immediately if you have back pain, flushing, shortness of breath, chest tightness or difficulty in breathing. Your doctor may need to stop the drip immediately. These side effects may occur in the first 10 minutes of infusion and go away when the infusion is slowed or stopped.

Other side effects include any of the following: mouth sores, hair loss, headache, dizziness, difficulty in breathing, nausea, vomiting, diarrhoea, abdominal pain, weakness, tiredness, fever and chills.

Daunorubicin (liposomal) may cause the vein at the injection site to swell and become painful. Inform doctor immediately if you experience any stinging or burining sensation along the vein. Accidental leakage of this medicine onto skin may cause skin injury. Alert your doctor quickly if it occurs.

Daunorubicin (liposomal) may cause damage to the heart muscle. This side effect can occur early during the treatment or within months after the last dose of this medicine . Inform your doctor quickly if you have irregular heartbeat, are overly tired, have shortness of breath even when resting or doing simple daily activities, have swollen ankles or feet or have gained weight due to water retention.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:

- breathlessness, or develop swelling or flushing of face, swelling of the lips, tongue, throat, hands or feet, rashes, itchy or runny nose
- swelling, pain, tingling sensation and blistering of the palms or soles

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:

- vaccines e..g. flu vaccine, hepatitis vaccine, chicken pox vaccine
- medicines for heart disease e.g. digoxin, dipyridamole, quinidine, nicardipine
- medicines for epilepsy (seizures or fits) e.g. phenytoin, carbamazepine
- medicines for HIV and hepatitis e.g. ritonavir, telaprevir
- other medicines for cancer e.g. tamoxifen, vinblastine, docetaxel

This list does not include all medicines that may interact with Daunorubicin (liposomal).

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in the refrigerator, between 2-8 °C. Do not allow to freeze. If frozen, this medicine will become ineffective and should not be used.

Store Daunorubicin (liposomal) in its original carton to protect from light.

Keep away from the reach of children.

Medicines must not be used past the expiry date.

This information is independently developed by MIMS based on Daunorubicin - Intravenous (Liposomal) and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2022 MIMS. All rights reserved. Powered by MIMS.com
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