Dermovate特美膚

Dermovate

clobetasol

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig
/
Agencia Lei Va Hong
Concise Prescribing Info
Contents
Clobetasol propionate
Indications/Uses
Psoriasis (excluding widespread plaque psoriasis), recalcitrant dermatoses, lichen planus & discoid lupus erythematosus; other skin conditions which do not respond satisfactorily to less potent steroids.
Dosage/Direction for Use
Cream Appropriate for moist or weeping surfaces. Oint Appropriate for dry, lichenified or scaly lesions. Adult, elderly & childn >1 yr Apply thinly & gently rub in using only enough to cover the entire affected area once daily or bd until improvement occurs. Then, reduce the frequency of application or change the treatment to a less potent prep. Allow adequate time for absorption after each application before applying an emollient. Max wkly dose should not exceed 50 g/wk.
Contraindications
Hypersensitivity. Untreated cutaneous infections; rosacea; acne vulgaris; pruritus w/o inflammation; perianal & genital pruritus; perioral dermatitis. Dermatoses in childn <1 yr, including dermatitis & nappy eruptions.
Special Precautions
Patients w/ a history of local hypersensitivity to other corticosteroids or to any of the excipients in the prep. W/draw gradually or substitute a less potent corticosteroid in case of manifestations of hypercortisolism (Cushing's syndrome) & reversible hypothalamic-pituitary-adrenal (HPA) axis suppression. In childn & infants, courses should be limited if possible to 5 days & reviewed wkly; occlusion should not be used. Infection risk w/ occlusion. Use w/ caution in patients w/ psoriasis. Appropriate antimicrobial therapy should be used whenever treating inflammatory lesions which have become infected. Higher occurrence of local hypersensitivity reactions & increased risk of local infection when used to treat dermatitis around chronic leg ulcers. If applied to the face, courses should be limited to 5 days if possible & occlusion should not be used. If applied to the eyelids, care is needed to ensure that the prep does not enter the eye, as cataract & glaucoma might result from repeated exposure. If Dermovate does enter the eye, the affected eye should be bathed in copious amounts of water. Contains propylene glycol which may cause skin irritation. Pregnancy & lactation. Cream Contains cetostearyl alcohol & chlorocresol.
Adverse Reactions
Drug Interactions
Increased systemic exposure w/ CYP3A4 inhibitors (eg, ritonavir, itraconazole).
MIMS Class
Topical Corticosteroids
ATC Classification
D07AD01 - clobetasol ; Belongs to the class of very potent (group IV) corticosteroids. Used in the treatment of dermatological diseases.
Presentation/Packing
Form
Dermovate cream 0.05 %
Packing/Price
30 g x 1's
Form
Dermovate oint 0.05 %
Packing/Price
30 g x 1's
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