Desloratadine: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the local prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Allergic conditions

Adult: 5 mg once daily.
Child: 6-11 mth 1 mg; 1-5 yr 1.25 mg; 6-11 yr 2.5 mg. Doses to be taken once daily.

Renal Impairment

Initially, 5 mg every other day.

Hepatic Impairment

Initially, 5 mg every other day.

Administration

May be taken with or without food.

Special Precautions

Hepatic and renal impairment. Pregnancy and lactation.

Adverse Reactions

Pharyngitis, dry mouth, myalgia, fatigue, somnolence, headache, dizziness, insomnia, dysmenorrhoea, nausea, dyspepsia, diarrhoea, vomiting, anorexia, increased appetite, fever, UTI, varicella, upper resp tract infection, coughing, epistaxis, parasitic infection, bronchitis, otitis media, rhinorrhoea, emotional lability, irritability, maculopapular rash, erythema.

Pregnancy Category (US FDA)

PO: C

Drug Interactions

Potential increase in plasma concentrations w/ drugs affecting hepatic microsomal enzymes (e.g. azithromycin, cimetidine, erythromycin, fluoxetine, ketoconazole).

Food Interaction

May increase CNS depression w/ alcohol.

Action

Description: Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H₁-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Onset: W/in 1 hr.
Duration: 24 hr.
Pharmacokinetics:
Absorption: Time to peak plasma concentration: Approx 3 hr.
Distribution: Distributed into breast milk. Plasma protein binding: Approx 82-87%.
Metabolism: Extensively metabolised to 3-hydroxydesloratadine (active metabolite), which subsequently undergoes glucuronidation.
Excretion: Via urine and faeces as metabolites (approx 87%). Elimination half-life: 27 hr.

Storage

Store between 15-30°C.

MIMS Class

Antihistamines & Antiallergics

References

Anon. Desloratadine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 12/03/2014.

Buckingham R (ed). Desloratadine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com . Accessed 12/03/2014.

Clarinex (Merck Sharp & Dohme Corp.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/.

McEvoy GK, Snow EK, Miller J et al (eds). Desloratadine. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 12/03/2014.

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