Docusate sodium

Generic Medicine Info
Indications and Dosage
Adult: 50-300 mg daily in divided doses. Max: 500 mg daily.
Child: ≥12 yr Same as adult dose.

Bowel evacuation
Adult: As adjunct to abdominal radiological procedures: 400 mg given w/ barium meal.
Child: ≥12 yr Same as adult dose.

Softening of ear wax
Adult: As 0.5% drops: Apply sufficient amount to fill the affected ear(s) on not more than 2 consecutive nights, before syringing if needed.
Child: Same as adult dose.

Adult: As 283 mg/5 mL enema: 1 enema 1-3 times daily.
Child: ≥12 yr Same as adult dose.
Presence of abdominal pain, nausea, vomiting, intestinal obstruction. Perforation of ear drum or ear inflammation (otic).
Special Precautions
Rectal admin in patient w/ haemorrhoids or anal fissures. Childn. Pregnancy and lactation.
Adverse Reactions
Anorectal pain or bleeding (rectal). Rarely, diarrhoea, abdominal cramps, nausea, skin rash.
Perform periodic rectal examinations in patients w/ impaired rectal function (esp loss of sensation) during rectal admin.
Symptoms: Oral: Excessive loss of water and electrolytes. Otic: Skin irritation. Management: Oral: Encourage patient to drink plenty of fluid. Replenish electrolyte loss where appropriate. Otic: Symptomatic treatment.
Drug Interactions
May enhance GI uptake of other drugs (e.g. liquid paraffin). May increase effects of anthraquinone laxatives. Increased incidence of adverse effects in GI mucosa w/ aspirin.
Description: Docusate Na acts primarily by increasing the penetration of fluid into the faeces. It may also have effects on intestinal fluid secretion, and probably act both as stimulant and faecal softening agent. It also softens ear wax through penetration into the dry matrix of the ceruminous mass, reducing it into semi-solid debris.
Onset: 12-72 hr (oral); 2-15 min (rectal).
Absorption: Absorbed from the GI tract.
Distribution: Enters breast milk.
Excretion: Via bile.
Store between 15-30°C. Protect from freezing, heat, humidity and light.
ATC Classification
A06AA02 - docusate sodium ; Belongs to the class of softeners, emollients laxatives.
Anon. Docusate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. Accessed 02/11/2015.

Buckingham R (ed). Docusates. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. . Accessed 02/11/2015.

Docusol Liquid (Enemeez Inc. DBA Summit Pharmaceuticals). DailyMed. Source: U.S. National Library of Medicine. Accessed 02/11/2015.

Joint Formulary Committee. Docusate Sodium. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. Accessed 02/11/2015.

Disclaimer: This information is independently developed by MIMS based on Docusate sodium from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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