Hypersensitivity to the active substances, or to any of the excipients listed in Description.
Hypersensitivity to other beta-blockers.
Reactive airway disease including bronchial asthma, or a history of bronchial asthma, severe chronic obstructive pulmonary disease.
Sinus bradycardia, sick sinus syndrome, including sino-atrial block, second or third degree atrioventricular block not controlled with pace-maker. Overt cardiac failure, cardiogenic shock.
Severe allergic rhinitis and corneal dystrophies.