HIGHLIGHT
Dupixent

Dupixent

dupilumab

Manufacturer:

Sanofi

Distributor:

Zuellig
/
Four Star
Concise Prescribing Info
Contents
Dupilumab
Indications/Uses
Moderate to severe atopic dermatitis in adults & adolescents ≥12 yr who are candidates for systemic therapy. Add-on maintenance treatment for severe asthma w/ type 2 inflammation characterised by raised blood eosinophils &/or raised FeNO in adults & adolescents ≥12 yr who are inadequately controlled w/ high dose inhaled corticosteroid (ICS) plus another medicinal product for maintenance treatment.
Dosage/Direction for Use
SC Atopic dermatitis Adult Initially 600 mg (two 300-mg inj consecutively administered at different inj site), followed by 300 mg every other wk. Adolescent weighing ≥60 kg Initially 600 mg, followed by 300 mg every other wk, <60 kg Initially 400 mg (two 200-mg inj consecutively administered at different inj site), followed by 200 mg every other wk. Asthma Adult & adolescent ≥12 yr Initially 400 mg, followed by 200 mg every other wk. Patients w/ severe asthma & who are on oral corticosteroids, patients w/ severe asthma & comorbid moderate to severe atopic dermatitis Initially 600 mg, followed by 300 mg every other wk.
Contraindications
Special Precautions
Should not be used to treat acute asthma symptoms or acute exacerbations; acute bronchospasms or status asthmaticus. Discontinue immediately if systemic hypersensitivity reaction (immediate or delayed) occurs. Eosinophilic conditions in adult asthma patients. Patients w/ pre-existing helminth infections should be treated before initiating dupilumab. Conjunctivitis-related events. Atopic dermatitis patients w/ comorbid asthma. Do not concurrently give live & live attenuated vaccines. Patients w/ hepatic impairment or severe renal impairment. Pregnancy & lactation. Childn <12 yr.
Adverse Reactions
Atopic dermatitis: Inj site reactions. Conjunctivitis, oral herpes; eosinophilia; headache; conjunctivitis allergic, eye pruritus, blepharitis. Asthma: Inj site erythema. Inj site oedema, pain & pruritus.
MIMS Class
Antiasthmatic & COPD Preparations / Other Dermatologicals
ATC Classification
D11AH05 - dupilumab ; Belongs to the class of agents for atopic dermatitis, excluding corticosteroids. Used in the treatment of atopic dermatitis.
Presentation/Packing
Form
Dupixent soln for inj 200 mg/1.14 mL
Packing/Price
2 × 1's
Form
Dupixent soln for inj 300 mg/2 mL
Packing/Price
2 × 1's
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