Decreased plasma conc or loss of virologic response w/ drugs that induce CYP3A [eg, carbamazepine, oxcarbazepine, phenobarb, phenytoin, rifampin, rifapentine, dexamethasone (systemic), St. John's wort, rifabutin] or increase gastric pH (eg, proton pump inhibitors, antacids, H2
-receptor antagonists). Increased plasma conc w/ CYP3A inhibitors (eg, darunavir/ritonavir, lopinavir/ritonavir, other boosted PIs, unboosted PIs, azole antifungals, macrolide antibiotics, grapefruit juice). Not recommended to co-administer w/ other NNRTIs. Caution when co-administered w/ drugs that prolong the QTc interval; drugs that can disrupt electrolyte levels, drugs w/ known risk of Torsade de Pointes. Didanosine should be administered on an empty stomach & at least 2 hr before or at least 4 hr after Edurant. Adjustment of methadone maintenance therapy may be needed in some patients.