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One gram of ENCAIN cream pressed out of a tube of 30g is approximately 3.5 cm.
Persons frequently applying or removing cream should ensure that contact is avoided in order to prevent the development of hypersensitivity.
Adolescents ≥ 12 years: As for adults (approximately 2 g ENCAIN applied under an occlusive dressing for a minimum of 60 minutes, maximum 5 hours).
Term newborn infants, infants and children ≤ 11 years: In term newborn infants and infants < 3 months, only one single dose should be applied in any 24 hour period.
For children aged 3 months and above, a maximum of 2 doses, separated by at least 12 hours can be given within any 24 hour period. If, based on clinical need, a decision is nevertheless taken to use two applications in children under the age of 3 months.
The safety of ENCAIN in pre-term newborn infants has not been established. Use of ENCAIN is not recommended in pre-term infants.
Use of ENCAIN is not recommended in infants less than 3 months of age receiving treatment with methaemoglobin-inducing drugs.
For all age groups analgesic efficacy may decline if the skin application time is more than 5 hours. Procedures on intact skin should begin soon after the occlusive dressing is removed.
On the genital mucosa analgesic efficacy declines after 10-15 minutes and therefore the procedure should be commenced immediately.
Methods of dose estimation:
ENCAIN is available in 5 g and 30 g tubes. To dispense 1 g of ENCAIN from either tube size, apply the cream to a circular area with a diameter of approx. 18 mm (a 1 pence coin) and depth of approx. 4 to 5 mm.
If high levels of accuracy in dosing are required to prevent overdose (i.e. at doses approaching the maximum in neonates or if two applications may be required in a 24 h period), a syringe can be used where 1 ml = 1 g.
A string of cream can be used to define the quantity of ENCAIN administered from the 30 g tube where 1 g = 3.5 cm; however, a string of cream may not be appropriate for all application needs, e.g. when administering a low dose to small surface areas.