Endoxan

Endoxan

cyclophosphamide

Manufacturer:

Baxter Healthcare

Distributor:

Baxter Healthcare
/
Firma Chun Cheong
Concise Prescribing Info
Contents
Cyclophosphamide monohydrate.
Indications/Uses
Leukemias, malignant lymphomas, metastasizing & non-metastasizing malignant solid tumors, progressive autoimmune diseases, immunosuppressive treatment in organ transplantations.
Dosage/Direction for Use
Tab 1-4 tab daily in the morning. Inj Continuous treatment 3-6 mg/kg daily. Intermittent treatment 10-15 mg/kg at intervals of 2-5 days. High-dose intermittent treatment 20-40 mg/kg at intervals of 21-28 days.
Contraindications
Hypersensitivity. Severely impaired bone marrow function (especially patients pre-treated w/ cytotoxic agents &/or radiotherapy). Inflammation of the bladder. Urinary outflow obstructions, active infections. Pregnancy & lactation.
Special Precautions
Obstruction of the efferent urinary tract, cystitis, infections & electrolyte imbalance. Elderly & debilitated patients, previous radiotherapy, DM, chronic hepatic or renal impairment. Pre-existing heart disease. Weakened immune system. Monitor blood count. Ensure adequate fluid intake. May affect ability to drive or operate machinery.
Adverse Reactions
Blood & bone marrow disorders, GI disturbances, kidney & efferent urinary tract changes. Cystitis. Azoospermia or persistent oligospermia, ovulation disorders, amenorrhea. Disturbance of hepatic function. Veno-occlusive disease. Chronic interstitial pulmonary fibrosis, cardiomyopathy. Secondary tumors. Alopecia, pigment changes in palms, finger nails & soles.
Drug Interactions
Sulfonylureas, allopurinol, hydrochlorothiazide, phenobarb, phenytoin, benzodiazepines, chloral hydrate, vaccines, muscle relaxants, chloramphenicol, anthracyclines, pentostatin, indomethacin, alcohol, grapefruit.
ATC Classification
L01AA01 - cyclophosphamide ; Belongs to the class of alkylating agents, nitrogen mustard analogues. Used in the treatment of cancer.
Presentation/Packing
Form
Endoxan sugar-coated tab 50 mg
Packing/Price
50's
Form
Endoxan powd for inj 1 g
Packing/Price
1's
Form
Endoxan powd for inj 200 mg
Packing/Price
1's
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