Entigin肝敵清

Entigin Dosage/Direction for Use

entecavir

Manufacturer:

Yung Shin

Distributor:

Yung Shin
Full Prescribing Info
Dosage/Direction for Use
Entecavir should be administered on an empty stomach (at least 2 hours after a meal and 2 hours before the next meal).
Recommended Dosage: The recommended dose of entecavir for chronic hepatitis B virus infection in nucleoside-treatment-naive adults and adolescents 16 years of age and older is 0.5mg once daily.
The recommended dose of entecavir in adults and adolescents (≥16 years of age) with a history of hepatitis B viremia while receiving lamivudine or known lamivudine resistance mutations is 1mg once daily.
Renal Impairment: In subjects with renal impairment, the apparent oral clearance of entecavir decreased as creatinine clearance decreased. Dosage adjustment is recommended for patients with creatinine clearance <50ml/min, including patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD), as shown in Table 1. (See Table 1.)

Click on icon to see table/diagram/image

Hepatic Impairment: No dosage adjustment is necessary for patients with hepatic impairment.
Duration of Therapy: The optimal duration of treatment with entecavir for patients with chronic hepatitis B infection and the relationship between treatment and long-term outcomes (such as cirrhosis and hepatocellular carcinoma) are unknown.
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