Patients w/ infection, HTN, DM, osteoporosis, peptic ulcer, newly created intestinal anastomoses, psychoses, cardiac insufficiency, glaucoma or cataracts, family history of diabetes or glaucoma. Chickenpox & measles may worsen. Can reduce response of HPA-axis to stress. Discontinuation should be gradual. Risk of hypercorticism & adrenal suppression when used chronically in excessive doses. Patients w/ hepatic impairment. Avoid co-administration w/ CYP3A4 inhibitors eg, ketoconazole & grapefruit juice. Risk of adrenocortical suppression in newborn child. Pregnancy. Childn.