Limited data are available with regard to overdose in humans. A single dose of Entresto 583 mg sacubitril/617 mg valsartan and multiple doses of 437 mg sacubitril/463 mg valsartan (14 days) were studied in healthy volunteers and were well tolerated.
Hypotension is the most likely symptom of overdose due to the blood pressure lowering effects of Entresto. Symptomatic treatment should be provided.
The medicinal product is unlikely to be removed by haemodialysis due to high protein binding.