Epirubicin – intravesical

Patient Medicine Information
Why do I need this medicine?
Epirubicin is used on its own or together with other medicine to treat bladder cancer.

This medicine may also be used to prevent recurrence of bladder cancer after surgery.
How do I use this medicine?
Epirubicin is to be given directly into the bladder (intravesical) through a tube (catheter).

You will need to rest in the hospital ward or clinic while you are receiving this medicine. Your doctor or nurse will administer the injection for you.

The dose of Epirubicin will be decided by your doctor. Your doctor will advise you on the course of your treatment depending on your condition.
What should I do if I have forgotten to use this medicine?
Ensure that you keep all appointments with your doctor so that you do not miss any doses. Your doctor also needs to regularly monitor your response to Epirubicin.

If you miss an appointment or miss an injection, alert your doctor or nurse. A replacement appointment or injection should be given as soon as possible.
When should I not use this medicine?
Alert your doctor if you have the following conditions:
  • bladder infections
  • pain or inflammation of the bladder
  • contracted bladder
  • tumours that have penetrated the bladder wall
  • blood in the urine
  • conditions causing difficulty in introduction of the catheter into the bladder
as Epirubicin may not be suitable for you.

Do not use Epirubicin if you are pregnant or planning to have a baby soon. If you become pregnant while on this medicine, alert your doctor immediately. Epirubicin may cause harm to your unborn child. Both men and women must use proven birth control methods while being treated with this medicine. You may wish to discuss birth control methods with your doctor. Avoid pregnancy or fathering a child for at least six (6) months after you stop taking this medicine.

Do not breastfeed while you are being treated with Epirubicin.

DO NOT take Epirubicin with cimetidine, a medicine used to neutralise stomach acid.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • kidney disease
  • previous chest radiotherapy
Inform your doctor if you have been recently vaccinated. The vaccine may not work well or may cause an infection when used together with Epirubicin. Do not receive any vaccinations without first asking your doctor.

Do not participate in activities in which you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises) or bleeding that takes a long time to stop (e.g. too much bleeding when you floss or brush your teeth).

Avoid strenuous exercise and activities like going to the sauna. Drink more water to prevent dehydration.

For as long as you are using Epirubicin, you may need to have routine tests such as urine cytology (test to look for abnormal cells in your urine), blood count, and bladder examination. Your doctor will advise you about how often you need to have these tests. Keep your appointments with your doctor.
What side effects could I experience?
Epirubicin may cause any of the following side effects: incontinence, slow urination, painful or difficult urination, frequent urination especially at night, blood in the urine, and bladder discomfort.

This medicine may cause red discolouration of your urine for up to 2 days after your treatment. Do not be alarmed.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I use this with other medicines?
Do not take Epirubicin with cimetidine, a medicine used to neutralise stomach acid.

Inform your doctor and pharmacist if you are taking any of these medicines:
  • other medicines for cancer e.g. paclitaxel, docetaxel, trastuzumab, mitomycin C, cyclophosphamide, fluorouracil, cisplatin
  • medicine to treat TB (lung infection known as tuberculosis) e.g. rifampicin
  • medicines for high blood pressure or heart disease e.g. verapamil, nifedipine
  • medicines used in organ transplant or certain immune disorders e.g. ciclosporin
  • other medicines that may affect your bone marrow e.g. chloramphenicol, sulfonamides
This list does not include all medicines that may interact with Epirubicin.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
As the storage temperatures are product specific, please check with your doctor or pharmacist on how it should be stored.

Store Epirubicin in its original carton to protect from light.

Keep away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on epirubicin – intravesical and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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