Like all medicines, Esomeprazole Actavis can cause side effects, although not everybody gets them.
If the patient notices any of the following serious side effects, stop taking Esomeprazole Actavis and contact a physician immediately: Sudden wheezing, swelling of the lips, tongue and throat or body, rash, fainting or difficulties in swallowing (severe allergic reaction).
Reddening of the skin with blisters or peeling. There may also be severe blisters and bleeding in the lips, eyes, mouth, nose and genitals. This could be 'Stevens-Johnson syndrome' or 'toxic epidermal necrolysis'.
Yellow skin, dark urine and tiredness which can be symptoms of liver problems.
These effects are rare (may affect up to 1 in 1,000 people).
Other side effects include: Common (may affect up to 1 in 10 people):
Headache; effects on the stomach or gut: diarrhoea, stomach pain, constipation, wind (flatulence); feeling sick (nausea) or being sick (vomiting).
Uncommon (may affect up to 1 in 100 people):
Swelling of the feet and ankles; disturbed sleep (insomnia); dizziness, tingling feelings such as "pins and needles", feeling sleepy; spinning feeling (vertigo); dry mouth; changes in blood tests that check how the liver is working; skin rash, lumpy rash (hives) and itchy skin; fracture of the hip, wrist or spine (if Esomeprazole Actavis is used in high doses and over long duration).
Rare (may affect up to 1 in 1,000 people):
Blood problems such as reduced number of white blood cells or platelets- this can cause weakness, bruising or make infections more likely; low levels of sodium in the blood- this may cause weakness, being sick (vomiting) and cramps; feeling agitated, confused or depressed; taste changes; eyesight problems such as blurred vision; suddenly feeling wheezy or short of breath (bronchospasm); an inflammation of the inside of the mouth; an infection called "thrush" which can affect the gut and is caused by a fungus; liver problems, including jaundice which can cause yellow skin, dark urine, and tiredness; hair loss (alopecia); skin rash on exposure to sunshine; joint pains (arthralgia) or muscle pains (myalgia); generally feeling unwell and lacking energy; increased sweating.
Very Rare (may affect up to 1 in 10,000 people):
Changes in blood count including agranulocytosis (lack of white blood cells); aggression; seeing, feeling or hearing things that are not there (hallucinations); severe liver problems leading to liver failure and inflammation of the brain; sudden onset of a severe rash or blistering or peeling skin- this may be associated with a high fever and joint pains (erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis); muscle weakness; severe kidney problems; enlarged breasts in men.
Esomeprazole may in very rare cases affect the white blood cells leading to immune deficiency. If the patient has an infection with symptoms such as fever with a severely reduced general condition or fever with symptoms of a local infection such as pain in the neck, throat or mouth or difficulties in urinating, the patient must consult the physician as soon as possible so that a lack of white blood cells (agranulocytosis) can be ruled out by a blood test. It is important for the patient to give information about the medication at this time.
Not Known (frequency cannot be estimated from the available data):
If the patient is on Esomeprazole for more than three months it is possible that the levels of magnesium in the blood may fall. Low levels of magnesium can be seen as fatigue, involuntary muscle contractions, disorientation, convulsions, dizziness, increased heart rate. If the patient gets any of these symptoms, please tell the physician promptly. Low levels of magnesium can also lead to a reduction in potassium or calcium levels in the blood. The physician may decide to perform regular blood tests to monitor the levels of magnesium.
Inflammation in the gut (leading to diarrhoea).