Estrofem

Estrofem

estradiol

Manufacturer:

Novo Nordisk

Distributor:

Firma Chun Cheong
/
DKSH
Concise Prescribing Info
Contents
Estradiol hemihydrate
Indications/Uses
Hormone replacement therapy (HRT) in post-menopausal women, particularly in women who have had hysterectomy. Relief of menopausal symptoms. Prevention of osteoporosis.
Dosage/Direction for Use
1 tab daily at about the same time each day.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Known, suspected or history of breast cancer; known, suspected or history of oestrogen-sensitive cancer eg, endometrial cancer; unexpected vag bleeding; untreated endometrial hyperplasia; thrombosis eg, DVT or pulmonary embolism; blood clotting disorder eg, protein C, protein S or antithrombin deficiency; known or recent disease caused by arterial blood clots eg, heart attack, stroke or angina; liver disease & liver function tests have not returned to normal; porphyria.
Special Precautions
Premature menopause. Use cautiously in patients w/ fibroids inside the womb; endometriosis or history of endometrial hyperplasia; increased risk of blood clots; increased risk of oestrogen-sensitive cancer; HTN; liver disorder eg, benign liver tumour; diabetes; gallstones; migraine or severe headaches; autoimmune disorders eg, SLE; epilepsy; asthma; otosclerosis; hypertriglyceridemia; fluid retention due to cardiac or kidney problems. Discontinue use in case of jaundice; HTN; migraine-like headaches occurring for the 1st time; pregnancy; signs of blood clots eg, painful swelliing & redness of legs, sudden chest pain & difficulty in breathing. Increased risk of memory loss in women >65 yr. May affect results of some laboratory tests. Lactose intolerance.
Adverse Reactions
Depression, headache, abdominal pain, nausea, leg cramps, breast pain, tenderness or enlargement, oedema, increased wt.
Drug Interactions
Reduced effectiveness w/ anti-epileptics (eg, phenobarb, phenytoin & carbamazepine), anti-TB (eg, rifampicin, rifabutin), anti-HIV (eg, nevirapine, efavirenz, ritonavir & nelfinavir) & St. John's wort.
ATC Classification
G03CA03 - estradiol ; Belongs to the class of natural and semisynthetic estrogens used in estrogenic hormone preparations.
Presentation/Packing
Form
Estrofem tab 1 mg
Packing/Price
28's
Form
Estrofem tab 2 mg
Packing/Price
28's
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