Do not take Estrofem: If any of the following applies. If patient is not sure about any of the points as follows, talk to the doctor before taking Estrofem.
Do not take Estrofem: If patient has or has ever had breast cancer, or if suspected of having it.
If the patient has or has had cancer which is sensitive to oestrogens, such as cancer of the womb lining (endometrium), or if the patient is suspected of having it.
If patient has any unexplained vaginal bleeding.
If patient has excessive thickening of the womb lining (endometrial hyperplasia) that is not being treated.
If patient has or has ever had a blood clot in a vein (thrombosis), such as in the legs (deep venous thrombosis) or the lungs (pulmonary embolism).
If patient has a blood clotting disorder (such as protein C, protein S or antithrombin deficiency).
If patient has or recently has had a disease caused by blood clots in the arteries, such as a heart attack, stroke or angina.
If patient has or has ever had a liver disease and the liver function tests have not returned to normal.
If patient has a rare blood problem called 'porphyria' which is passed down in families (inherited).
If patient is allergic (hypersensitive) to estradiol or any of the other ingredients of Estrofem (listed in Description).
If any of the previously mentioned conditions appear for the first time while taking Estrofem, patient should stop taking it at once and consult a doctor immediately.