Some medicines may interfere with the effects of Estrofem. This might lead to irregular bleeding. This applies to the following medicines: Medicines for epilepsy (such as phenobarbital, phenytoin and carbamazepin); Medicines for tuberculosis (such as rifampicin, rifabutin); Medicines for HIV infection (such as nevirapine, efavirenz, ritonavir and nelfinavir); Herbal remedies containing St. John's Wort (Hypericum perforatum).
Please tell the doctor or pharmacist if the patient is taking or has recently taken any other medicines, including medicines obtained without a prescription, herbal medicines or other natural products.
Taking Estrofem with food and drink: The tablets can be taken with or without food and drink.