Risk of developing hypersensitivity reactions; MI & stroke; hypocalcaemia; osteonecrosis of the jaw & atypical femoral fractures. Patients should be adequately supplemented w/ Ca & vit D. Greater risk of developing hypocalcaemia in patients w/ severe renal impairment (eGFR 15-29 mL/min/1.73 m2
) or receiving dialysis. Not indicated for use in women of child-bearing potential. Not indicated in pregnancy & lactation.