Exelon憶思能

Exelon

rivastigmine

Manufacturer:

Novartis

Distributor:

Zuellig
/
Four Star
Concise Prescribing Info
Contents
Rivastigmine hydrogen tartrate
Indications/Uses
Mild to moderately severe dementia associated w/ Alzheimer's disease or Parkinson's disease.
Dosage/Direction for Use
Initially 1.5 mg bd. May be increased if well tolerated after a min of 2 wk of treatment to 3 mg bd. Subsequent dose increase to 4.5 mg bd up to a max of 6 mg bd may be considered based on good tolerability of current dose. Patients sensitive to the effects of cholinergic drugs Initially 1 mg bd.
Administration
Should be taken with food.
Contraindications
Hypersensitivity to rivastigmine or to other carbamate derivatives. History of application site reactions suggestive of allergic contact dermatitis w/ rivastigmine transdermal patch.
Special Precautions
If treatment is interrupted for >3 days, it should be re-initiated w/ lowest daily dose. GI disorders may occur at initiation of therapy & shortly after dose increase. Monitor patient's wt during therapy. Sick sinus syndrome, conduction defects (SA & AV blocks); predisposed to increased gastric acid secretion, urinary obstruction & seizures; history of asthma or obstructive pulmonary disease. May induce or exacerbate extrapyramidal symptoms. Discontinue if allergic contact dermatitis occur. Patient <50 kg body wt. Hepatic & renal impairment. May impair ability to drive or operate machinery. Pregnancy & lactation. Ped patient.
Adverse Reactions
Nausea, vomiting, diarrhoea, loss of appetite, dizziness. Abdominal pain, dyspepsia; headache, somnolence, tremor; agitation, confusion, nightmares, anxiety; fatigue, asthenia, malaise; hyperhydrosis; wt loss.
Drug Interactions
Possible additive extrapyramidal effect w/ metoclopramide. Additive effects w/ other cholinomimetic drugs; anticholinergic drugs (eg, oxybutynin, tolterodine). May exaggerate the effects of succinylcholine-type muscle relaxants during anaesth. Additive effects leading to bradycardia w/ β-blockers. Increased oral clearance w/ nicotine.
ATC Classification
N06DA03 - rivastigmine ; Belongs to the class of anticholinesterases. Used in the management of dementia.
Presentation/Packing
Form
Exelon cap 3 mg
Packing/Price
28's
Form
Exelon cap 1.5 mg
Packing/Price
28's
Form
Exelon cap 4.5 mg
Packing/Price
28's
Form
Exelon cap 6 mg
Packing/Price
28's
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