Feburic菲布力

Feburic

febuxostat

Manufacturer:

Astellas

Distributor:

Firma Chun Cheong
/
DKSH
Concise Prescribing Info
Contents
Febuxostat
Indications/Uses
Treatment of chronic hyperuricaemia in adults where urate deposition has already occurred (including history or presence of tophus &/or gouty arthritis). Feburic 120 mg is also indicated for prevention & treatment of hyperuricaemia in adult patients undergoing chemotherapy for haematologic malignancies at intermediate to high risk of Tumor Lysis Syndrome (TLS).
Dosage/Direction for Use
Gout 80 mg once daily. TLS 120 mg once daily; start 2 days before the beginning of cytotoxic therapy & continue for a min of 7 days.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Not recommended in patients w/ ischaemic heart disease or CHF; Lesch-Nyhan syndrome; organ transplant patients. Closely monitor patients for symptoms of allergic/hypersensitivity reactions. Gout flares may occur during treatment initiation. Perform liver function test prior to treatment initiation & periodically thereafter based on clinical judgment. Use w/ caution in patients w/ altered thyroid function. Rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Concomitant use w/ mercaptopurine/azathioprine. Severe renal impairment. Moderate to severe hepatic impairment. May impair ability to drive or operate machinery. Should not be used during pregnancy & lactation. Childn <18 yr.
Adverse Reactions
Gout flares, liver function abnormalities, diarrhoea, nausea, headache, rash, oedema.
Drug Interactions
Increased plasma conc of mercaptopurine/azathioprine. Possible increased metabolism & decreased efficacy w/ potent UGT enzyme inducers. Naproxen, NSAIDs, probenecid & other inhibitors of glucuronidation could in theory affect the elimination of febuxostat.
ATC Classification
M04AA03 - febuxostat ; Belongs to the class of preparations inhibiting uric acid production. Used in the treatment of gout.
Presentation/Packing
Form
Feburic FC tab 80 mg
Packing/Price
28's
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