Ovarian stimulation regimens for assisted reproduction in infertility
Adult: For the development of multiple follicles in women undergoing assisted reproductive technologies such as in vitro fertilisation or intracytoplasmic sperm inj cycle: 1st treatment cycle: Doses are based on the serum anti-Mullerian hormone (AMH) concentration (within the last 12 months) and body weight; doses must be maintained throughout the stimulation period: AMH <15 pmol/L: 12 mcg daily, irrespective of body weight; AMH ≥15 pmol/L: Daily dose decreases from 0.19 to 0.10 mcg/kg by increasing AMH concentration; refer to specific product guidelines. Max: 12 mcg daily. Initiate treatment on day 2 or 3 after the start of menstrual bleeding, continued until adequate follicular development which is usually obtained by the 9th day of treatment (range: 5-20 days); thereafter, hCG should be given to induce final follicular maturation. For patients with excessive ovarian response, stop treatment and induction of final follicular maturation with hCG. Subsequent treatment cycles: Daily doses are based on patient's ovarian response to the previous cycle: Adequate response: Maintain daily dose; Hypo-response: Increase daily dose by 25% or 50%; Hyper-response: Decrease daily dose by 20% or 33%. Doses are adjusted based on the observed extent of response. Max: 24 mcg daily.