Fresofol 1% MCT/LCT

Fresofol 1% MCT/LCT



Fresenius Kabi


The Glory Medicina
Concise Prescribing Info
Induction & maintenance of general anaesth, sedation for diagnostic & surgical procedures, alone or in combination w/ local or regional anaesth in adult & childn >1 mth, sedation of ventilated patients >16 yr of age in the ICU.
Dosage/Direction for Use
IV Induction of anaesth Adult <55 yr 1.5-2.5 mg/kg. Patient w/ ASA grades III & IV Approx 20 mg every 10 sec. Childn >1 mth 2.5 mg/kg, 1 mth to 3 yr 2.5-4 mg/kg. Maintenance of anaesth 4-12 mg/kg/hr as continuous infusion. Elderly, unstable general conditions impaired cardiac function or hypovolaemic & ASA grades III & IV 4 mg/kg. Repeat bolus inj of 25-50 mg should be given. Childn >1 mth 9-15 mg/kg/hr as continuous infusion. Sedation Patient >16 yr of age in ICU 0.3-4 mg/kg/hr as continuous infusion. Sedation for diagnostic & surgical procedures Adult 0.5-1 mg/kg over 1-5 min for onset of sedation. Maintenance of sedation: 1.5 mg/kg/hr. May be supplemented by bolus administration of 10-20 mg. Childn >1 mth 1-2 mg/kg for onset. Maintenance of sedation: 1.5-9 mg/kg/hr. May be supplemented by bolus administration of up to 1 mg/kg.
Hypersensitivity to propofol, soya, peanut or to any of the excipient of Fresofol 1% MCT/LCT. Patient ≤16 yr for sedation in intensive care.
Special Precautions
Cardiac, resp, renal or hepatic impairment, or hypovolaemic or debilitated patients. Concomitant use w/ drugs known to reduce cardiac output. May impair ability to drive or operate machinery. Pregnancy & lactation.
Adverse Reactions
During induction: Local pain, bradycardia, tachycardia, transient apnoea, coughing, singultus. During recovery: headache, nausea, vomiting. Hypotension.
Drug Interactions
Lower dose when used as adjunct to regional anaesth technique. Profound hypotension w/ rifampicin. Reduced resp rate & prolonged anaesth w/ benzodiazepines, parasympatholytic agents or inhalational anaesth. Intensified & prolonged sedative effects w/ opioid. Potentiated anaesth & CV side effects w/ premedication, inhalation agents or analgesic agents. Intensified sedative effects w/ alcohol, general anaesth, narcotic analgesic; severe resp & CV depression w/ centrally depressant drugs. Increased blood level & rate of apnoea w/ fentanyl. Bradycardia & cardiac arrest w/ suxamethonium or neostigmine. Leucoencephalopathy w/ cyclosporine. Consider dose reduction when used concomitantly w/ valproate.
MIMS Class
Anaesthetics - Local & General
ATC Classification
N01AX10 - propofol ; Belongs to the class of other general anesthetics.
Fresofol 1% MCT/LCT emulsion for inj/infusion 1%
20 mL x 5 × 1's;50 mL x 1's
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/hongkong/image/info/fresofol 1percent mct-lct emulsion for inj-infusion 1percent/1percent x 50 ml?id=8f5ae7ca-d9aa-4ea4-9c82-acd7010aa807
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