Use in the ICU in pregnancy & lactation: The safety of propofol during pregnancy has not been established. Therefore, propofol should not be used in pregnant women unless clearly necessary. Propofol crosses the placenta and may be associated with neonatal depression.
High doses (>2.5 mg propofol/kg body weight for induction or 6 mg propofol/kg body weight/hr for maintenance of anaesthesia) should be avoided.
Studies in breastfeeding women showed that propofol is excreted in small amounts into the milk. Therefore, mothers should stop breastfeeding and discard breast milk for 24 hrs after administration of propofol.