Glimepiride - oral

Patient Medicine Information
Why do I need this medicine?
Glimepiride is used to treat diabetes by keeping your blood sugar in control.

Glimepiride is meant to be taken as part of a complete diabetes care programme that should include exercise, a healthy diet and regular monitoring of blood sugar levels.
How do I take this medicine?
Take Glimepiride exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take this medicine just before your first main meal of the day. Do not skip your meals after taking this medicine.

Glimepiride must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Do not take Glimepiride if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to similar sulfonamides or sulfonylureas such as glipizide, tolbutamide, sulfamethoxazole, or sulfasalazine.

Alert your doctor if you have the following conditions:
  • type 1 diabetes (a condition in which the pancreas produces little or no insulin)
  • severe kidney disease
  • severe liver disease
  • complications of diabetes such as diabetic ketoacidosis (ketone bodies and sugar in your urine) and diabetic coma (episodes of unconsciousness)
as Glimepiride may not be suitable for you.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • G6PD deficiency (an inherited blood disorder that affects the red blood cells)
  • stress-related states e.g. fever, trauma, infection, surgery
  • mild to moderate kidney disease
  • mild to moderate liver diseas
Let your doctor know if you are pregnant or breastfeeding.

Keep your appointments with your doctor. Your doctor may need to do blood tests to monitor your condition and check your response to the medication regularly.

If you are going for an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking Glimepiride.

If you are taking this medicine, you may have been warned about hypoglycaemia (low blood sugar).

How do I know if I am experiencing hypoglycaemia?

Hypoglycaemia is the medical term for low blood sugar. Symptoms of hypoglycaemia include dizziness, tremor, shaky hands, feeling hungry, weak or confused, sweating. These signs are your body’s way of warning you that your blood sugar level is low.

It is important to recognise these symptoms and get relief for hypoglycaemia quickly, as the hypoglycaemia may worsen.

What should I do if I am experiencing hypoglycaemia?

Always carry some glucose tablets (also known as dextrose tablets) with you. Take 15 g of glucose tablet at first sign of hypoglycaemia, wait for 15 minutes and re-check your blood sugar level. If you are not feeling better or if your blood sugar level is still low (less than 4 mmol/L or 70 mg/dL), take another 15 g of glucose tablet.

If you don’t have glucose tablets, you may take any of the following:
  • 1/2 cup (120 mL) of juice or regular soda (not diet)
  • 1 tablespoon of sugar, honey, or corn syrup
  • hard candies, jellybeans, or gumdrops (not sugar-free)
Get medical help should symptoms did not improve after second serving.
What side effects could I experience?
Glimepiride may cause hypoglycaemia (low blood sugar) and visual disturbances. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include: headache, nausea, dizziness, stomach pain, and diarrhoea.

Alert your doctor quickly if you experience rashes with skin peeling or blisters / rashes with peeling of the skin or blistering of the lips, mouth or eyes accompanied by fever.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for fungal infections e.g. miconazole, fluconazole
  • medicine for diabetes e.g. insulin, metformin
  • medicines for TB e.g. rifampicin, isoniazid
  • medicines supporting muscle build up e.g. anabolic steroids
  • some antibiotics e.g. chloramphenicol, clarithromycin
  • medicine for epilepsy (fits) e.g. phenytoin, barbiturates
  • asthma medicine e.g. albuterol, terbutaline
  • medicine to treat cancer e.g. cyclophosphamide
  • cholesterol-lowering medicines e.g. fibrates
  • medicines for pain and inflammation e.g. phenylbutazone, aspirin
  • blood-thinning medicines e.g. warfarin
  • medicines for high blood pressure or heart disease e.g. disopyramide, metoprolol, diazoxide
  • medicines for mood disorder e.g. fluoxetine, chlorpromazine
  • medicines for gout e.g. allopurinol, probenecid
  • water pill e.g. thiazide diuretics
Inform your doctor if you are currently taking birth control pills as this can reduce the effectiveness of Glimepiride. You should not stop or start any birth control pills without first informing your doctor. Ask your doctor about using non-hormonal birth control as an alternative while being treated with this medicine.

This list does not include all medicines that may interact with Glimepiride.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.

It is important to maintain a healthy diet and weight to help keep your diabetes under control.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on glimepiride - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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