amlodipine + valsartan


Kolmar Korea


Hind Wing
Four Star
Concise Prescribing Info
Amlodipine 5 mg, valsartan 80 mg
Essential HTN in adults whose BP is not adequately controlled on amlodipine or valsartan monotherapy.
Dosage/Direction for Use
Hypersensitivity. Severe hepatic impairment, biliary cirrhosis or cholestasis. Severe hypotension. Shock (including cardiogenic shock). Obstruction of the outflow tract of the left ventricle (eg, hypertrophic obstructive cardiomyopathy & high grade aortic stenosis). Haemodynamically unstable heart failure after acute MI. Concomitant use w/ aliskiren-containing products in patients w/ DM or renal impairment (GFR <60 mL/min/1.73 m2). 2nd & 3rd trimesters of pregnancy.
Special Precautions
Risk of symptomatic hypotension in Na &/or vol-depleted patients. Hyperkalaemia. Angioedema w/ valsartan. Patients w/ unilateral or bilateral renal artery stenosis or stenosis to a solitary kidney; recent kidney transplantation; hepatic impairment or biliary obstructive disorders; severe renal impairment; primary hyperaldosteronism; heart failure/post-MI; mitral stenosis or significant aortic stenosis that is not high grade. Monitoring of K levels & creatinine is advised in moderate renal impairment. Dual blockade of the renin-angiotensin-aldosterone system (RAAS) w/ ACE inhibitors, angiotensin II receptor blockers or aliskiren. Mild or moderate influence on the ability to drive & use machines. Should not be initiated during pregnancy. Not recommended during breastfeeding. Elderly. Childn <18 yr.
Adverse Reactions
Nasopharyngitis, influenza; hypokalaemia; headache; asthenia, fatigue, facial oedema, flushing, hot flush, oedema, oedema peripheral, pitting oedema.
Drug Interactions
Higher frequency of adverse events w/ combined use of ACE inhibitors, angiotensin II receptor blockers or aliskiren.
MIMS Class
Angiotensin II Antagonists / Calcium Antagonists
ATC Classification
C09DB01 - valsartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.
Hiforge 5/80 mg tab
2 × 14's
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