Patients of reproductive age should use contraceptives during therapy & for the following 6 mth. Unilateral nephrectomies; obstruction of efferent urinary tract, cystitis, brain metastases, cerebral symptoms, infection, electrolyte imbalance. Patients w/ previous radiotherapy. DM, hepatic & renal impairment. Concomitant use w/ nephrotoxic drugs. Timely administration of antiemetics. Regular monitoring of renal function, urinalysis & blood count. Ensure adequate diuresis & meticulous oral hygiene. May impair ability to drive or operate machinery. Elderly.