Humalog Mix25/Humalog Mix50

Humalog Mix25/Humalog Mix50 Side Effects

insulin lispro + insulin lispro protamine


Eli Lilly


Agencia Lei Va Hong
Full Prescribing Info
Side Effects
Like all medicines, Humalog Mix25/Humalog Mix50 can cause side effects, although not everybody gets them.
Local allergy is common (≥1/100 to <1/10). Some people get redness, swelling or itching around the area of the insulin injection. This usually clears up in anything from a few days to a few weeks. If this happens, tell the doctor.
Systemic allergy is rare (≥1/10,000 to <1/1,000). The symptoms are as follows: rash over the whole body; blood pressure dropping; difficulty in breathing; heart beating fast; wheezing; sweating.
If the patient is having this sort of insulin allergy with Humalog Mix25/Humalog Mix50, tell the doctor at once.
Lipodystrophy (thickening or pitting of the skin) is uncommon (≥1/1,000 to <1/100). If there is skin thickening or pitting at the injection site, tell the doctor.
Oedema (e.g. swelling in arms, ankles; fluid retention) has been reported, particularly at the start of insulin therapy or during a change in therapy to improve control of the blood glucose.
Reporting of side effects: If the patient gets any side effects, talk to the doctor or pharmacist. This includes any possible side effects not previously listed. The patient can also report side effects directly via the Drug office, Department of Health. By reporting side effects, it can help provide more information on the safety of this medicine.
Common problems of diabetes: Hypoglycaemia: Hypoglycaemia (low blood sugar) means there is not enough sugar in the blood. This can be caused if: The patient takes too much Humalog Mix25/Humalog Mix50 or other insulin; the patient misses or delays meals or change of diet; the patient exercises or works too hard just before or after a meal; the patient has an infection or illness (especially diarrhoea or vomiting); there is a change in the need for insulin; or the patient has trouble with kidneys or liver which gets worse.
Alcohol and some medicines can affect the blood sugar levels.
The first symptoms of low blood sugar usually come on quickly and include the following: Tiredness; rapid heartbeat; nervousness or shakiness; feeling sick; headache; cold sweat.
While the patient is not confident about recognising any warning symptoms, avoid situations, e.g. driving a car, in which the patient or others would be put at risk by hypoglycaemia.
Hyperglycaemia and diabetic ketoacidosis: Hyperglycaemia (too much sugar in the blood) means that the body does not have enough insulin. Hyperglycaemia can be brought about by: Not taking Humalog or other insulin; taking less insulin than the doctor prescribed; eating a lot more than the diet allows; or fever, infection or hormonal stress.
Hyperglycaemia can lead to diabetic ketoacidosis. The first symptoms come on slowly over many hours or days. the symptoms include the following: Feeling sleepy; no appetite; flushed face; fruity smell on the breath; thirst; feeling or being sick.
Severe symptoms are heavy breathing and rapid pulse. Get medical help immediately.
Illness: If the patient is ill, especially if feeling sick or is sick, the amount of insulin needed may change. Even when the patient is not eating normally, insulin is still needed. Urine or blood tests should be done, 'sick rules' should be followed, and inform the doctor.
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