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Indications and Dosage
Oral
Oedema Adult: 50-100 mg daily in 1-2 divided doses, may reduce to 25-50 mg on alternate days or intermittently. Max: 200 mg daily. Oral Hypertension Adult: Initial dose: 12.5 mg daily. Usual dose: 25-50 mg daily alone or in conjunction with other antihypertensives.
Child: 1 mg/kg daily, may reduce dose for maintenance. |
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Contraindications
Severe hepatic or renal impairment; anuria; Addison's disease; hypercalcaemia. Pregnancy and lactation.
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Special Precautions
Fluid and electrolyte disturbances; hepatic cirrhosis; gout; DM. Elderly; severe heart failure; renal or hepatic impairment. Monitor blood glucose concentrations in patients taking antidiabetics.
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Adverse Reactions
Electrolyte imbalance; hyperglycaemia; gout; dry mouth; thirst; weakness; muscle pain and cramp; seizures; hypotension; GI disturbances; anorexia; sialadenitis; headache; impotence; yellow vision; hypersensitivity reactions; cholestatic jaundice; pancreatitis; blood dyscrasias; glycosuria; dizziness; photosensitivity reactions, postural hypotension, paraesthesia.
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Overdosage
Lethargy, nausea, weakness and electrolyte imbalance, possibly progress to coma within a few hr with minimal depression of respiratory and CV function and with no evidence of dehydration or serum electrolyte changes. GI irritation and hypermotility, temporary elevation of the BUN, serum electrolyte changes (e.g. hypokalemia, hypochloremia, hyponatremia) may occur in renally impaired patients. Empty stomach by inducing vomiting with ipecac syrup If patient is conscious. Cathartics should not be admin as they may promote loss of fluid and electrolytes. Supportive and symptomatic treatment with monitoring of serum electrolytes, renal, respiratory, and CV function. Replace fluid and electrolytes where necessary.
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Drug Interactions
Digitalis glycosides; drugs that prolong QT interval; other antihypertensives; competitive muscle relaxants; pressor amines; corticosteroids, corticotrophin; β2-agonists, α-blockers; ACE inhibitors; NSAIDs; alcohol, barbiturates; opioids; lithium; Allopurinol; tetracyclines; carbenoxolone; hypoglycaemics.
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Action
Description: Hydroflumethiazide reduces the reabsorption of electrolytes from the renal tubules, hence increasing the excretion of sodium and chloride ions and consequently of water. It also reduces the glomerular filtration rate.
Onset: 2 hr. Duration: 24 hr. Pharmacokinetics: Absorption: Incompletely but fairly rapidly absorbed from the GI tract. Excretion: Excreted in the urine. |
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MIMS Class
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