Imuran依木蘭

Imuran

azathioprine

Manufacturer:

Aspen Asia

Distributor:

Cordial Trading
/
Primal
Concise Prescribing Info
Contents
Azathioprine
Indications/Uses
In combination w/ corticosteroids &/or other immunosuppressive agents & procedures, to enhance the survival of renal, cardiac & hepatic transplants & reduce the corticosteroid requirement of renal transplant. Alone or in combination w/ corticosteroids &/or other drugs & procedures in severe RA, SLE, dermatomyositis & polymyositis, autoimmune chronic active hepatitis, pemphigus vulgaris, polyarteritis nodosa, autoimmune haemolytic anaemia, chronic refractory idiopathic thrombocytopenic purpura.
Dosage/Direction for Use
Transplantation Up to 5 mg/kg/day on the 1st day of therapy. Maintenance dose: 1-4 mg/kg/day. Other Conditions Initially 1-3 mg/kg/day. Maintenance dose: <1 to 3 mg/kg/day.
Administration
May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Special Precautions
Monitor complete blood count during therapy, in severe renal &/or hepatic disorder. Perform liver function tests regularly to patients w/ hepatic dysfunction. Limit exposure to sunlight & UV light, wear protective clothing & use a sunscreen w/ a high protection factor for patients w/ increased risk for skin cancer. History of varicella zoster virus (VZV) infection. Pregnancy & lactation.
Adverse Reactions
Viral, fungal & bacterial infections. Bone marrow depression, leucopenia, thrombocytopenia, nausea. Uncommonly, anaemia, hypersensitivity reactions, pancreatitis,cholestasis, liver function test deterioration.
Drug Interactions
Metabolism inhibited by allopurinol, oxipurinol & thiopurinol. Reduces the neuromuscular blockade of tubocurarine but potentiates that of succinylcholine. Inhibits anticoagulant effect of warfarin. Penicillamine, co-trimoxazole, captopril, cimetidine & indomethacin; aminosalicylates eg olsalazine, mesalazine or sulfasalazine, furosemide, hepatitis B vaccine.
ATC Classification
L04AX01 - azathioprine ; Belongs to the class of other immunosuppressants.
Presentation/Packing
Form
Imuran tab 50 mg
Packing/Price
100's
Form
Imuran tab 25 mg
Packing/Price
100's
Form
Imuran powd for inj 50 mg
Packing/Price
1's
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