Aspen Asia


Cordial Trading
Concise Prescribing Info
Active stages of RA, OA, ankylosing spondylitis, degenerative joint disease of the hip, acute musculoskeletal disorders, gout & lumbago. Inflammation, pain & oedema following orthopaedic procedures. Treatment of pain & associated symptoms of primary dysmenorrhoea.
Dosage/Direction for Use
Adult 50-200 mg daily. Acute RA Initially 25 mg bd-tds. Chronic rheumatic disorders 25 mg bd-tds. If response is inadequate, gradually increase by 25 mg. Sudden flare up of chronic condition Increase if necessary, by 25 mg daily until a satisfactory response is obtained, or a dose of 150-200 mg daily is reached. Acute musculoskeletal disorders Initially 50 mg bd-tds, according to severity for 10-14 days. Lumbago 50 mg bd-tds, according to severity. Gout Acute attack: 50 mg 3-4 times daily until symptoms subside. Following orthopaedic procedures Normally 100-150 mg daily in divided doses until symptoms subside. Patients who require a dose of 150-200 mg/day Dose may be gradually reduced to a maintenance level of 75-100 mg/day. Patients w/ persistent night pain &/or morning stiffness Dose of up to 100 mg at bed time.
Should be taken with food: Take immediately after meals.
Hypersensitivity to indomethacin, ibuprofen, aspirin, other NSAIDs, or any of the excipients. Severe heart, hepatic & renal failure. Not to be used in patients who have nasal polyps. During the last trimester of pregnancy. Safety in childn has not been established. Active, or history of recurrent peptic ulcer/haemorrhage (≥2 distinct episodes of proven ulceration or bleeding). History of GI bleeding or perforation, related to previous NSAIDs therapy. For the treatment of peri-operative pain in the setting of CABG surgery.
Special Precautions
Increased risk of serious CV thrombotic events, including MI, stroke & heart failure; HTN; CHF, fluid retention & peripheral oedema. Patients who may be at greater risk of developing serious GI events. Impaired renal function; advanced renal disease. Patients w/ underlying haemostatic defects. Concurrent use w/ warfarin & other anticoagulants. May impair ability to drive or operate machinery. 1st 2 trimesters of pregnancy. Lactation. Childn <2 yr. Elderly.
Adverse Reactions
Headache, dizziness, light-headedness, depression, vertigo & fatigue. Nausea, anorexia, vomiting, epigastric distress, abdominal pain, constipation, & diarrhoea.
Drug Interactions
Increased GI toxicity w/ acetylsalicylic acid, diflusinal & other NSAIDs. Increased levels w/ probenecid. Decreased tubular secretion of methotrexate. Increased toxicity of cyclosporine. Increased plasma conc of lithium. Reduced effects of diuretics. Increased serum K w/ K-sparing diuretics. Do not administer w/ triamterene. Attenuated effects of antihypertensive agents, β-adrenergic receptor blocking agents. Co-administration w/ AIIA or ACE inhibitors may result in further deterioration of renal function. Increased serum conc of digoxin.
ATC Classification
M01AB01 - indometacin ; Belongs to the class of acetic acid derivatives and related substances of non-steroidal antiinflammatory and antirheumatic products.
Indocid cap 25 mg
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