Indocid Mechanism of Action



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Full Prescribing Info
ATC Code: M01A B01.
Pharmacology: Pharmacodynamics: Indomethacin is a non-steroidal anti-inflammatory agent with analgesic and antipytretic properties.
The analgesic properties have been attributed to both central and peripheral effect, which are distinct from its anti-inflammatory activity.
Pharmacokinetics: Absorption: Indomethacin is readily absorbed from the gastrointestinal tract; peak plasma concentrations are reached in about 0.5-2 hours after a dose.
Distribution: More than 90% is bound to plasma proteins. It is distributed into synovial fluid, CNS and placenta. Low concentrations have been found in breast milk.
Metabolism: It is metabolised in the liver primarily by demethylation and deacetylation, it also undergoes glucuronidation and enterohepatic circulation. Half-life is between 3-11 hours.
Elimination: Mainly excreted in the urine, approximately 60%, the pH of the urine can affect this amount. Lesser amounts in the faeces. Indomethacin is also excreted in milk in small amounts.
Toxicology: Preclinical Safety Data: Carcinogenesis, Mutagenesis, and Impairment of Fertility: There are no pre-clinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC.
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