Instillagel Mechanism of Action




Full Prescribing Info
Combined action of lubricant, mucosal anesthetic and anti-microbial takes place when instilled into the urethra.
Used for catheterization, endoscopies, gynecologic examination and rectum and colon examination.
Complete coverage of the entire urethra with lubricant protects the mucosa and prevents the incidence of such strictures following transurethral instrumentation.
Due to the reduced pain when inserting a catheter, end users have significantly less stress.
Unlike conventional catheterization, the lubricant gel does not get pushed out but instilled thoroughly into the urethra.
Unlike plane lubricant gel, the lubricating film covers the entire urethra during catheterization from one instillation.
No concern about the possible bacterial infection from the gel being put around the catheter before insertion.
The urethra is dilated to provide the maximum pathway for the incoming catheter.
Lubricant: Effective insertion while reducing trauma: The unbroken coating of lubricant reduces the danger of injury to the vulnerable urothelium.
The lubricating film reduces friction between foreign objects (catheters) and the mucosa, and allows the catheter to glide painlessly into the bladder.
The single instillation of Instillagel provides a maximum coverage over the entire urethra.
Since the urethral canal is dilated before insertion, it reduces the actual intubation time.
Instillagel is clear and does not impair visualization during endoscopy.
The viscosity of Instillagel is ideal for the insertion of catheter and other instruments.
Anesthetic: Pain relieving: Pain-free catheterization and internal urethrotomy are possible after the instillation of 2% lidocaine gel into the urethra.
Instillagel provides sufficient urethral anesthesia and reduces the risk of injury as a result of the patient's involuntary defensive movements.
Anesthetic effect occurs 3~5 minutes after the instillation and maintained for 30 minutes.
No side effects attributable to the administration of Instillagel were recorded.
Disinfectant: Antiseptic and against infection: Instillagel prevents the risk of nosocomial infections due to catheterization and cystoscopy.
As Instillagel contains the constituents lidocaine hydrochloride, chlorhexidine digluconate and methyl and propyl 4-hydroxybenzoate it works as a local anaesthetic and an antibacterial agent against all relevant pathogens.
With Saccharomyces cerevisiae, Streptococcus pyogenes, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, an entire extinction is obtained by Instillagel already within 5 minutes.
The unbroken coating of lubricant builds a protection against bacteria.
Shown as an effective treatment for urethritis as a local antiseptic therapy.
Antimicrobial action of Instillagel: See table.

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Catheter-Associated Urinary Tract Infections (CAUTI): Effective Infection management for CAUTI which takes 30% of the total nosocomial infection: According to the Centers for Disease Control and Prevention (CDC) in the US, the mortality rate from nosocomial infections was ranked 4th following cardiovascular disease, cancer and cerebrovascular disease. This morality rate is higher than accidental death including traffic accidents. Nosocomial infections are causing a large number of deaths even in developed countries alarming the infection control surveillance and management at hospitals.
The nosocomial infection rate is 6~8% out of the total number of patients and the urinary tract infection (UTI) takes up to 40~45% out of the total nosocomial infections. Among that, 70~80% of the infection is catheter-associated (daily incidence rate of 3-10%) and that causes the total CAUTI rate of 30% out of the total nosocomial infections.
The most critical factor of UTI is the indwelling period of a catheter. It has been reported that the infection rate per urethral catheterization is 1%, 10~40% when the indwelling period is less than a week and 100% when indwelling longer than 28 days. There are two commonly known infection courses: When bacteria access form the exterior surface of a catheter (65%); When bacteria ascent along the interior surface of a catheter (35%). (See figure.)

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Bacteria from urethral meatus may access to the bladder via a catheter.
The major causative bacteria of CAUTI still is E. coli (25~35%) which is mostly caused from ascending infection during catheterization.
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