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Hepatic encephalopathy
Adult: As 3.335 g/5 mL solution: Initially, 30-45 mL 3-4 times daily, may be adjusted as necessary to achieve 2 or 3 soft stools daily.
Oral
Constipation
Adult: As 3.335 g/5 mL solution or 10 g/15 mL single dose solution sachet: Initially, 15-45 mL (10-30 g or 1-3 sachets) daily, may be adjusted according to clinical response. Maintenance dose: 15-30 mL (10-20 g or 1-2 sachets) daily. All doses may be given as single daily dose or in 2 divided doses. Therapeutic effect may occur after 2-3 days of treatment. As powder for solution: 10-20 g daily, may increase to 40 g daily if necessary.
Child: <1 year As 3.335 g/5 mL solution: Initially, up to 5 mL daily. Maintenance dose: Up to 5 mL daily. 1-6 years As 3.335 g/5 mL solution: Initially, 5-10 mL daily. Maintenance dose: 5-10 mL daily. 7-14 years As 3.335 g/5 mL solution or 10 g/15 mL single dose solution sachet: Initially, 15 mL (10 g or 1 sachet) daily, may be adjusted according to clinical response. Maintenance dose: 10-15 mL (10 g or 1 sachet) daily. >14 years Same as adult dose. All doses may be given as a single daily dose or in 2 divided doses.
Child: <1 year As 3.335 g/5 mL solution: Initially, up to 5 mL daily. Maintenance dose: Up to 5 mL daily. 1-6 years As 3.335 g/5 mL solution: Initially, 5-10 mL daily. Maintenance dose: 5-10 mL daily. 7-14 years As 3.335 g/5 mL solution or 10 g/15 mL single dose solution sachet: Initially, 15 mL (10 g or 1 sachet) daily, may be adjusted according to clinical response. Maintenance dose: 10-15 mL (10 g or 1 sachet) daily. >14 years Same as adult dose. All doses may be given as a single daily dose or in 2 divided doses.
Rectal
Hepatic encephalopathy
Adult: Mix 200 g (300 mL) of solution with 700 mL of water or 0.9% NaCl: Administer as a retention enema via balloon catheter over 30-60 minutes, may be repeated every 4-6 hours until oral medication is possible.
