May be absorbed systemically. Patients w/ CV diseases; asthma; patients subject to spontaneous hypoglycaemia or w/ labile diabetes; history of atopy or of severe anaphylactic reaction; acute attacks of closed angle glaucoma. May mask signs & symptoms of acute hypoglycaemia & signs of hyperthyroidism. Concomitant therapy w/ oral β-blocking agent. May gradually increase iris pigmentation. Reports of macular edema including cystoids macular edema mainly in aphakic patients, pseudophakic patients w/ torn posterior lens capsule, or in patients w/ known risk factors for macular edema; choroidal detachment w/ administration of aqueous suppressant therapy after filtration procedures. Contains benzalkonium Cl. Remove contact lenses before instillation of eye drops; reinsert after 15 min. May impair ability to drive or operate machinery. Pregnancy & lactation. Childn & adolescents.