Latanoprost & Timolol Stada

Latanoprost & Timolol Stada Adverse Reactions

latanoprost + timolol

Manufacturer:

Stada

Distributor:

HK Medical Supplies
/
Health Express
Full Prescribing Info
Adverse Reactions
For Latanoprost, the majority of adverse events relate to the ocular system. Other ocular adverse events are generally transient and occur on dose administration. For Timolol, the most serious adverse events are systemic in nature, including bradycardia, arrhythmia, congestive heart failure, bronchospasm and allergic reactions.
Treatment related adverse events seen in clinical trials with Latanoprost and Timolol are listed as follows: Adverse events are categorized by frequency as follows: Very common (≥1/10), Common (≥1/100 to <1/10), Uncommon (≥1/1000 to <1/100), Rare (≥1/10,000 to <1/1000), Very rare (<1/10,000), Not known (cannot be estimated from the available data).
Nervous System Disorders: Uncommon: Headache.
Eye Disorders: Very common: Increased iris pigmentation.
Common: Eye irritation (including stinging, burning and itching), eye pain.
Uncommon: Eye hyperaemia, conjunctivitis, vision blurred, Lacrimation increased, blepharitis, Corneal disorders.
Skin and Subcutaneous Tissue Disorders: Uncommon: Skin rash, pruritus.
Additional adverse events have been reported specific to the use of the individual components of the medicinal product either in clinical studies, spontaneous reports or in available literature.
For Latanoprost, these are: Nervous System Disorders: Dizziness.
Eye Disorders: Eyelash and vellus hair changes (increased length, thickness, pigmentation and number), punctuate epithelial erosions, periorbital oedema, iritis/uveitis, macular oedema (in aphakic, pseudophakic patients with torn posterior lens capsules or in patients with known risk factors for macular oedema), dry eye, keratitis, corneal oedema and erosions, misdirected eyelashes sometimes resulting in eye irritation and iris cyst.
Cardiac Disorders: Aggravation of angina in patients with pre-existing disease, palpitations.
Respiratory, Thoracic, and Mediastinal Disorders: Asthma, asthma aggravation, dyspnoea.
Skin and Subcutaneous Tissue Disorders: Darkening of palpebral skin.
Musculoskeletal, Connective Tissue and Bone Disorder: Joint pain, muscle pain.
General Disorders and Administration Site Conditions: Chest pain.
For Timolol, these are: Immune System Disorders: Signs and symptoms of systemic allergic reactions including angioedema, urticaria and localized and general rash.
Psychiatric Disorders: Depression, insomnia, nightmares, memory loss.
Nervous System Disorders: Dizziness, paraesthesia, cerebral ischemia, cerebrovascular accident, increase in signs and symptoms of myasthenia gravis, syncope.
Eye Disorders: Signs and symptoms of ocular irritation (e.g. burning, stinging, itching, tearing, redness), blepharitis, keratitis, blurred vision and choroidal detachment following filtration surgery, decreased corneal sensitivity, dry eyes, corneal erosion, ptosis and diplopia.
Ear and Labyrinth Disorders: Tinnitus.
Cardiac Disorders: Palpitation, arrhythmia, bradycardia, cardiac arrest, atrioventricular block, congestive heart failure.
Vascular Disorders: Hypotension, Raynaud's phenomenon, cold hands and feet.
Respiratory, Thoracic and Mediastinal Disorders: Bronchospasm (predominantly in patients with pre-existing bronchospastic disease), dyspnoea, cough.
Gastrointestinal Disorder: Nausea, diarrhea, dyspepsia, dry mouth.
Skin and Subcutaneous Tissue Disorders: Alopecia, psoriasiform rash or exacerbations of psoriasis.
General Disorder and Administration Site Conditions: Asthenia, fatigue.
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