No data available in humans with regards to overdose with Latanoprost and Timolol.
Symptoms of systemic Timolol overdose are: bradycardia, hypotension, bronchospasm and cardiac arrest. If such symptoms occur the treatment should be symptomatic and supportive.
Apart from ocular irritation and conjunctival hyperaemia no other ocular or systemic side effects are known if Latanoprost is overdosed.
If Latanoprost is accidentally ingested orally the following information may be useful: Treatment: Gastric lavage if needed. Symptomatic treatment.
Latanoprost is extensively metabolised during the first pass through liver. Intravenous infusion of 3 micrograms/kg in healthy volunteers induced no symptoms but a dose of 5.5-10 micrograms/kg caused nausea, abdominal pain, dizziness, fatigue, hot flushes and sweating. These events were mild to moderate in severity and resolved without treatment, within 4 hours after terminating the infusion.