Initially 2 mg once daily; may be increased to 4 mg & if necessary to 6 mg. Hepatic impairment Initially 2 mg once daily. Renal impairment No dose modification required. Elderly Initially 2 mg once daily, increasing to 4-6 mg daily based on clinical response.
Congenital or documented acquired QT prolongation. Not for secondary prevention of MI. Efficacy & safety in the treatment of malignant HTN has not been established. Hepatic impairment. Pregnancy & lactation. Childn.