Levobunolol

Ophthalmic
Ocular hypertension, Open-angle glaucoma

Sick sinus syndrome, sinus bradycardia, 2nd and 3rd degree AV block, asthma or history of asthma, severe COPD, cardiogenic shock, overt cardiac failure.

Patients w/ diminished pulmonary function, nonallergic bronchospasm, inadequate cardiac function, DM, myasthenia gravis. May mask signs and symptoms of hypoglycaemia and hyperthyroidism. Avoid abrupt withdrawal as it may precipitate thyroid storm. Pregnancy and lactation.

Ocular stinging, burning, blepharoconjunctivitis, blepharitis, decreased visual acuity, band keratopathy, erythema, iridocyclitis, conjunctivitis and itching sensation; bradycardia, CVA, syncope, arrhythmia, heart block, hypotension, cerebral ischaemia, bronchospasm. Rarely, reduced corneal sensitivity and tearing.

Ophth: C

Do not drive or operate machinery until vision is clear.

Additive hypotensive effect w/ catecholamine-depleting drug (e.g. reserpine), Ca channel blockers, β-adrenergic blockers, digitalis glycosides, antiarrhythmics, guanethidine, parasympathomimetics. Mydriasis may occur when used w/ epinephrine.

Description: Levobunolol is a nonselective β-adrenergic blocking agent. It causes the reduction of intraocular pressure by decreasing the production of aqueous humour.
Onset: W/in 1 hr.
Duration: Up to 24 hr.
Pharmacokinetics:
Absorption: Some absorbed systematically.

Store between 15-30°C. Protect from light.

Antiglaucoma Preparations

Anon. Levobunolol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com.

Buckingham R (ed). Levobunolol Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com.

McEvoy GK, Snow EK, Miller J et al (eds). Levobunolol Hydrochloride (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com.