Levofloxacin-Pharmathen-I & C

Levofloxacin-Pharmathen-I & C



I & C


I & C
Concise Prescribing Info
Levofloxacin (as hemihydrate)
Treatment of infections caused by bacteria that are sensitive to levofloxacin: Infections of the lungs (in people w/ long-term breathing problems or pneumonia), urinary tract including kidneys & bladder, prostate gland, skin & soft tissue. Prevents development of inhalational anthrax following exposure to Bacillus anthracis.
Dosage/Direction for Use
IV Adult & elderly w/ normal kidney function 250-500 mg once daily or bd by slow infusion. Recommended infusion time: At least 30 min for 250 mg, or 60 min for 500 mg.
Hypersensitivity to levofloxacin or other active substances of the same group (ie, quinolones). Epilepsy; tendon problems. Pregnancy & lactation. Childn & adolescent.
Special Precautions
Examine patient for a potent tachycardia & a temporary decrease in BP during infusion. History of brain damage (eg, stroke or severe brain injury); tendon inflammation/complaints; pseudomembranous colitis; family history of or current G6PD deficiency; mental health problems; symptoms due to nerve damage eg, kinetic or sensory problems in hand & feet. Prolonged QT interval, salt imbalance in the blood, bradycardia, heart failure, MI. Skin may become more sensitive to light while on medication. Renal & hepatic impairment. Concomitant use w/ anticoagulants eg, warfarin; oral medicine that lowers blood glucose levels; medicines that result in abnormal ECG changes. Patients on a controlled Na diet & fluid restriction. May impair ability to drive & use machines. Pregnancy & lactation.
Adverse Reactions
Nausea, diarrhoea; increase in blood levels of liver enzymes.
Drug Interactions
Use w/ caution when co-administered w/ drugs known to prolong QT interval (eg, Class IA & III anti-arrhythmics, TCAs, macrolides, antipsychotics). Increased bleeding w/ vit K antagonist (eg, warfarin). Increased risk of seizures w/ theophylline or fenbufen; NSAIDs. Prolonged effect of ciclosporin. Increased probability of inflammation &/or breakage of tendons w/ corticosteroids.
MIMS Class
ATC Classification
J01MA12 - levofloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Levofloxacin-Pharmathen-I & C soln for infusion 500 mg/100 mL
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