Levothyroxine Actavis

Levothyroxine Actavis

levothyroxine sodium




Agencia Lei Va Hong
Concise Prescribing Info
Levothyroxine Na
Dosage/Direction for Use
Adult Initially 50-100 mcg/day, increased by 50 mcg every 3-4 wk up to max of 150-300 mcg/day, until normal metabolism is maintained. Patient >50 yr Initially no more than 50 mcg/day, >50 yr w/ heart disease 25 mcg/day or 50 mcg every other day. May be increased by 25 mcg/day every 4 wk. Childn Congenital hypothyroidism in infant Initially 10-15 mcg/kg/day for the 1st 3 mth. Adjust dose depending on response to treatment. Acquired hypothyroidism Initially 12.5-50 mcg/day, increase dose gradually every 2-4 wk depending on response to treatment. Juvenile myxoedema Initially 25 mcg/day, increased by 25 mcg every 2-4 wk. Slightly reduce dose if mild toxic symptoms appear. In childn >1 yr, initially 2.5-5 mcg/kg/day.
Should be taken on an empty stomach: Take 30 min-1 hr before meals.
Hypersensitivity. Thyrotoxicosis, untreated adrenal problems.
Special Precautions
Heart problems or recent heart attack; HTN; severe long-term hypothyroidism, underactive adrenal gland (eg, panhypopituitarism), diabetes. Increased bone resorption thereby decreased bone mineral density w/ long-term therapy in women. Intolerance to some sugars. Pregnancy & lactation. Elderly.
Adverse Reactions
Allergic reactions; tachycardia, irregular heart beats, palpitations, anginal pain; headache, restlessness, excitability, sleeping difficulty, flushing, sweating, fever, tremor, heat intolerance, diarrhoea, being sick, excessive wt loss; muscle cramps or weakness; partial hair loss during 1st few mth of therapy.
Drug Interactions
Antidiabetics (eg, insulin, metformin), digoxin, TCAs (eg, amitriptyline, dosulepin), epinephrine, anticoagulants (eg, warfarin, dicoumarol, acenocoumarol, phenindione), Na polystyrene sulphonate, colestyramine, medicines for stomach ulcers (eg, sucralfate, cimetidine), Al hydroxide, Ca carbonate, Fe tab, antiepileptics (eg, carbamazepine, phenytoin, phenobarb, primidone), rifampicin, aspirin, phenylbutazone, propranolol, medicines containing oestrogen, amiodarone, ketamine, lovastatin or colesevelam, orlistat, corticosteroids (eg, hydrocortisone, prednisolone), medicines containing testosterone & mesterolone. Potential interaction w/ ritonavir.
MIMS Class
Thyroid Hormones
ATC Classification
H03AA01 - levothyroxine sodium ; Belongs to the class of thyroid hormones.
Levothyroxine Actavis tab 100 mcg
Levothyroxine Actavis tab 50 mcg
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