Loperamide Stella

Loperamide Stella

loperamide

Manufacturer:

Stellapharm

Distributor:

HK Medical Supplies
/
Health Express
Concise Prescribing Info
Contents
Loperamide HCl
Indications/Uses
Symptomatic treatment of acute diarrhoea in adults & childn ≥12 yr; acute episodes of diarrhoea associated w/ irritable bowel syndrome (IBS) in adults ≥18 yr following initial diagnosis.
Dosage/Direction for Use
Initially 2 cap (4 mg), followed by 1 cap (2 mg) after every loose stool. Max: 6 cap (12 mg) daily.
Contraindications
Hypersensitivity. Patients w/ acute dysentery; acute ulcerative colitis; bacterial enterocolitis caused by invasive organisms including Salmonella, Shigella & Campylobacter; pseudomembranous colitis associated w/ use of broad-spectrum antibiotics. When avoiding inhibition of peristalsis due to possible risk of significant sequelae including ileus, megacolon & toxic megacolon. Childn <12 yr.
Special Precautions
Does not preclude administration of appropriate fluid & electrolyte replacement therapy. Should not be used for prolonged periods until underlying cause of diarrhoea has been investigated. In acute diarrhoea, discontinue administration if clinical improvement is not observed w/in 48 hr. Stop therapy at the earliest signs of abdominal distension in AIDS patients. Reports of obstipation w/ an increased risk for toxic megacolon in AIDS patients w/ infectious colitis from both viral & bacterial pathogens. Discontinue administration if clinical improvement is not observed w/in 48 hr in patients taking this medicine to control episodes of diarrhoea associated w/ IBS. Only take this medicine to treat acute episodes of diarrhoea associated w/ IBS if IBS was previously diagnosed. Patient ≥40 yr & it has been some time since last IBS attack or symptoms are different this time; patient recently passed blood from bowel; suffers from severe constipation; feeling sick or vomiting; lost appetite or wt; has difficulty or pain passing urine; w/ fever; recently travelled abroad. Reports of cardiac events including QT prolongation & torsades de pointes in association w/ overdose; do not exceed recommended dose &/or duration of treatment. Should not be taken by patients w/ rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption. May impair ability to drive or operate machinery. Patients w/ hepatic impairment. Not advisable to administer in pregnancy, especially during the 1st trimester. Not recommended during breast-feeding.
Adverse Reactions
Headache; constipation, nausea, flatulence.
Drug Interactions
Increased plasma conc w/ P-gp inhibitors eg, quinidine, ritonavir; CYP3A4 & P-gp inhibitors eg, itraconazole, ketoconazole; CYP2C8 inhibitors eg, gemfibrozil. Increased plasma conc of oral desmopressin. Potentiated effect w/ drugs that have similar pharmacological properties. Decreased effect w/ drugs that accelerate GI transit.
MIMS Class
Antidiarrheals
ATC Classification
A07DA03 - loperamide ; Belongs to the class of antipropulsives. Used in the treatment of diarrhea.
Presentation/Packing
Form
Loperamide Stella hard cap 2 mg
Packing/Price
5 × 10's
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