Losacor

Losacor

losartan

Manufacturer:

Sandoz

Distributor:

Zuellig
/
Agencia Lei Va Hong
Concise Prescribing Info
Contents
Losartan K
Indications/Uses
Essential HTN in adults, childn & adolescents 6-18 yr. Renal disease in adults w/ HTN & type 2 DM w/ proteinuria ≥0.5 g/day as part of antihypertensive treatment. Chronic heart failure in adults when ACE inhibitors are not considered suitable. Reduction in the risk of stroke in adult hypertensive patients w/ left ventricular hypertrophy documented by ECG.
Dosage/Direction for Use
HTN 50 mg once daily, may be increased to 100 mg daily. HTN & type II DM w/ proteinuria ≥0.5 g/day Initially 50 mg once daily, may be increased to 100 mg once daily. Heart failure Initially 12.5 mg once daily, titrated at wkly intervals (ie, 12.5 mg, 25 mg, 50 mg, 100 mg daily to max of 150 mg once daily) as tolerated by patient. Reduction in risk of stroke in hypertensive patients w/ left ventricular hypertrophy Initially 50 mg once daily, increased to 100 mg once daily. Patients w/ intravascular vol depletion Starting dose: 25 mg once daily. Childn 6-18 yr, >50 kg Usual dose: 50 mg once daily. Max: 100 mg once daily, >20-<50 kg Recommended dose: 25 mg once daily. Max: 50 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Concomitant use w/ aliskiren-containing products in patients w/ DM or renal impairment (GFR <60 mL/min/1.73 m2). Severe hepatic impairment. Pregnancy (2nd & 3rd trimester).
Special Precautions
Patients w/ history of angioedema; vol- &/or Na-depleted; renal artery stenosis or stenosis of the artery to a solitary kidney; heart failure; aortic or mitral valve stenosis or obstructive hypertrophic cardiomyopathy; ischaemic CV & cerebrovascular disease. Closely monitor K & CrCl especially in patients w/ heart failure & CrCl 30-50 mL/min. Not recommended in patients w/ primary aldosteronism. Dual blockade of the renin-angiotensin-aldosterone system (RAAS) through the combined use of ACE inhibitors, AIIAs or aliskiren. Concomitant use w/ ACE inhibitors; K-sparing diuretics, K supplements & K containing salt substitutes. Rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machinery. Monitor renal function regularly during treatment. Recent kidney transplantation. History of hepatic impairment; severe hepatic impairment. Black patients. Not recommended in 1st trimester of pregnancy. Lactation. Childn 6 mth to <6 yr. Childn w/ hepatic impairment, or w/ GFR <30 mL/min/1.73 m2.
Adverse Reactions
HTN: Dizziness, vertigo; hyperkalaemia. HTN w/ left ventricular hypertrophy: Dizziness, vertigo; asthenia, fatigue. Chronic heart failure: Dizziness, anaemia; orthostatic hypotension; renal impairment, renal failure; increase in blood urea, serum creatinine & serum K. HTN & type 2 DM w/ renal disease: Dizziness, orthostatic hypotension; asthenia, fatigue; hyperkalaemia; hypoglycaemia.
Drug Interactions
Increased risk of hypotension w/ other antihypertensives, TCAs, antipsychotics, baclofen, & amifostine. Decreased exposure to the active metabolite w/ fluconazole (CYP2C9 inhibitor). Reduced plasma conc w/ rifampicin (CYP2C9 inducer). Increased serum K w/ products which retain K (K-sparing diuretics eg, amiloride, triamterene, & spironolactone) or increase K levels (eg, heparin), K supplements or salt substitutes containing K. Reversible increase in lithium conc. Increased risk of worsening of renal function, increase in serum K & attenuation of antihypertensive effect w/ NSAIDs (ie, selective COX-2 inhibitors, acetylsalicylic acid at inflammatory doses & non-selective NSAIDs). Higher frequency of adverse reactions w/ ACE inhibitors, AIIAs, & aliskiren.
ATC Classification
C09CA01 - losartan ; Belongs to the class of angiotensin II receptor blockers (ARBs). Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Losacor FC tab 100 mg
Packing/Price
30's
Form
Losacor FC tab 50 mg
Packing/Price
30's
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