Madopar/Madopar Dispersible/Madopar HBS

Madopar/Madopar Dispersible/Madopar HBS

benserazide + levodopa

Manufacturer:

Roche

Distributor:

Firma Chun Cheong
/
DKSH
Concise Prescribing Info
Contents
Per Madopar 125 cap Levodopa 100 mg, benserazide 25 mg. Per Madopar 250 tab Levodopa 200 mg, benserazide 50 mg. Per Madopar Dispersible tab Levodopa 100 mg, benserazide 25 mg. Per Madopar HBS SR cap Levodopa 100 mg, benserazide 25 mg
Indications/Uses
Parkinson's disease, syndrome of parkinsonism excluding drug-induced parkinsonism. Dispersible tab For patients w/ dysphagia or where a more rapid onset of action is required.
Dosage/Direction for Use
Increase gradually to the optimal level (usually 4-8 cap/tab daily, equiv to 300-800 mg levodopa & 75-200 mg benserazide divided into ≥3 doses). Madopar Dispersible tab Should be taken w/in ½ hr of dissolving the tab.
Administration
Should be taken on an empty stomach: Take at least 30 min before or 1 hr after meals. May be taken w/ meals to reduce GI discomfort. Cap/HBS SR cap: Swallow whole, do not chew/crush. Dispersible tab: Disperse in ¼ glass of water (approx 25-50 mL). Stir before drinking & consume w/in 30 min.
Contraindications
Severely decompensated endocrine, renal, hepatic & cardiac disorders. Psychoses & severe psychoneuroses. Patients <25 yr. Pregnancy. Combination w/ MAOIs (except selegiline).
Special Precautions
Glaucoma. History of MI, coronary insufficiency, cardiac arrhythmia. Peptic ulcer & osteomalacia. Discontinue 1-2 days before surgery requiring general anesth.
Adverse Reactions
Anorexia, GI upsets (rare). Cardiac arrhythmias & orthostatic hypotension. Abnormal involuntary movements. Mild, transient leucopenia & thrombocytopenia (rare).
Drug Interactions
Potentiates effects of sympathomimetics. Neuroleptics, vit B6.
ATC Classification
N04BA02 - levodopa and decarboxylase inhibitor ; Belongs to the class of dopa and dopa derivative dopaminergic agents. Used in the management of Parkinson's disease.
Presentation/Packing
Form
Madopar 125 cap
Packing/Price
100's
Form
Madopar HBS SR cap
Packing/Price
100's
Form
Madopar 250 tab
Packing/Price
100's
Form
Madopar Dispersible (dispersible tab)
Packing/Price
100's
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