Acute active disease of the CNS eg, meningitis, tumours, poliomyelitis & cranial haemorrhage, active TB or metastatic lesions in the vertebral column. Septicaemia. Spinal stenosis & active disease (eg, spondylitis, tumour) or recent trauma (eg, fracture) in the vertebral column. Pernicious anaemia w/ subacute combined degeneration of the spinal cord. Pyrogenic infection of the skin at or adjacent to the site of puncture. Cardiogenic or hypovolaemic shock. Coagulation disorders or ongoing anticoagulant treatment.