Memantine Sandoz

Memantine Sandoz

memantine

Manufacturer:

Sandoz

Distributor:

Zuellig
Concise Prescribing Info
Contents
Memantine HCl
Indications/Uses
Moderate to severe Alzheimer's disease.
Dosage/Direction for Use
Adult Recommended starting dose: 5 mg/day, increased over the 1st 4 wk, reaching recommended maintenance dose: Wk 1 (day 1-7): 5 mg/day, wk 2 (day 8-14): 10 mg/day, wk 3 (day 15-21): 15 mg/day, from wk 4 on: 20 mg/day. Elderly >65 yr 20 mg/day. Moderate renal impairment (CrCl 30-49 mL/min) 10 mg/day, may be increased to 20 mg/day. Severe renal impairment (CrCl 5-29 mL/min) 10 mg/day.
Administration
May be taken with or without food.
Special Precautions
Epilepsy, history of convulsions or predisposing factors for epilepsy. Avoid concomitant use of N-methyl-D-aspartate (NMDA)-antagonists eg, amantadine, ketamine or dextromethorphan. Some factors that may raise urine pH may necessitate careful monitoring of the patient. Recent MI, uncompensated CHF (NYHA III-IV), uncontrolled HTN. Rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Severe hepatic impairment. May affect ability to drive or operate machinery. Pregnancy & lactation. Childn <18 yr.
Adverse Reactions
Drug hypersensitivity; somnolence; dizziness, balance disorders; HTN; dyspnoea; constipation; elevated liver function test; headache.
Drug Interactions
May enhance mode of action of L-dopa, dopaminergic agonists & anticholinergics. May reduce efficacy of barbiturates & neuroleptics. May modify effects of antispasmodic agents eg, dantrolene or baclofen. Increased risk of pharmacotoxic psychosis w/ amantadine, ketamine, dextromethorphan & phenytoin. Potential risk of increased plasma levels w/ cimetidine, ranitidine, procainamide, quinidine, quinine & nicotine. May reduce serum level of hydrochlorothiazide (HCT). Concomitant use w/ warfarin may increase INR.
ATC Classification
N06DX01 - memantine ; Belongs to the class of other anti-dementia drugs.
Presentation/Packing
Form
Memantine Sandoz FC tab 10 mg
Packing/Price
56's
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